Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites

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• 作者：Dan Zhou (13) (14)
  Donghui Zhang (13) (14)
  Guohui Ding (15)
  Linna Shi (13) (14)
  Qing Hou (13) (14)
  Yuting Ye (13) (14)
  Yang Xu (16)
  Huayun Zhou (17)
  Chunrong Xiong (17)
  Shengdi Li (15)
  Jing Yu (13) (14)
  Shanchao Hong (13) (14)
  Xinyou Yu (13) (14)
  Ping Zou (13) (14)
  Chen Chen (13) (14)
  Xuelian Chang (13) (14)
  Weijie Wang (13) (14)
  Yuan Lv (13) (14)
  Yan Sun (13) (14)
  Lei Ma (13) (14)
  Bo Shen (13) (14)
  Changliang Zhu (13) (14)
  
• 关键词：Genome ; Anopheles sinensis ; Malaria
• 刊名：BMC Genomics
• 出版年：2014
• 出版时间：December 2014
• 年：2014
• 卷：15
• 期：1
• 全文大小：582 KB
• 作者单位：Dan Zhou (13) (14)
  Donghui Zhang (13) (14)
  Guohui Ding (15)
  Linna Shi (13) (14)
  Qing Hou (13) (14)
  Yuting Ye (13) (14)
  Yang Xu (16)
  Huayun Zhou (17)
  Chunrong Xiong (17)
  Shengdi Li (15)
  Jing Yu (13) (14)
  Shanchao Hong (13) (14)
  Xinyou Yu (13) (14)
  Ping Zou (13) (14)
  Chen Chen (13) (14)
  Xuelian Chang (13) (14)
  Weijie Wang (13) (14)
  Yuan Lv (13) (14)
  Yan Sun (13) (14)
  Lei Ma (13) (14)
  Bo Shen (13) (14)
  Changliang Zhu (13) (14)
  
  13. Department of Pathogen Biology, Nanjing Medical University, Nanjing, Jiangsu, 210029, P.R. China
  14. Jiangsu Province Key Laboratory of Modern Pathogen Biology, Nanjing, Jiangsu, 210029, P.R. China
  15. Key Laboratory of Systems Biology, Shanghai Institutes for Biological Science, Shanghai, 200031, P.R. China
  16. Office of Research Administration, Nanjing Medical University, Nanjing, Jiangsu, 210029, P.R. China
  17. Jiangsu Institute of Parasitic Diseases, Wuxi, Jiangsu, 214064, P.R. China
  
• ISSN：1471-2164

文摘

Background Anopheles sinensis is an important mosquito vector of Plasmodium vivax, which is the most frequent and widely distributed cause of recurring malaria throughout Asia, and particularly in China, Korea, and Japan. Results We performed 454 next-generation sequencing and obtained a draft sequence of A. sinensis assembled into scaffolds spanning 220.8 million base pairs. Analysis of this genome sequence, we observed expansion and contraction of several immune-related gene families in anopheline relative to culicine mosquito species. These differences suggest that species-specific immune responses to Plasmodium invasion underpin the biological differences in susceptibility to Plasmodium infection that characterize these two mosquito subfamilies. Conclusions The A. sinensis genome produced in this study, provides an important resource for analyzing the genetic basis of susceptibility and resistance of mosquitoes to Plasmodium parasites research which will ultimately facilitate the design of urgently needed interventions against this debilitating mosquito-borne disease.