Important modifications by sugammadex, a modified γ-cyclodextrin, of ion currents in differentiated NSC-34 neuronal cells
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- 作者：Hung-Te Hsu ; Yi-Ching Lo ; Yan-Ming Huang ; Yu-Ting Tseng ; Sheng-Nan Wu
- 关键词：Sugammadex ; Motor neuron ; Delayed ; rectifier K+ current ; Activation kinetics ; L ; type Ca2+ current ; Glucocorticoid
- 刊名：BMC Neuroscience
- 出版年：2017
- 出版时间：December 2017
- 年：2017
- 卷：18
- 期：1
- 全文大小：2620KB
- 刊物主题：Neurosciences; Neurobiology; Animal Models;
- 出版者：BioMed Central
- ISSN：1471-2202
- 卷排序：18
文摘
BackgroundSugammadex (SGX) is a modified γ-cyclodextrin used for reversal of steroidal neuromuscular blocking agents during general anesthesia. Despite its application in clinical use, whether SGX treatment exerts any effects on membrane ion currents in neurons remains largely unclear. In this study, effects of SGX treatment on ion currents, particularly on delayed-rectifier K+ current [IK(DR)], were extensively investigated in differentiated NSC-34 neuronal cells.