Intermittent hypoxia causes NOX2-dependent remodeling of atrial connexins
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- 作者：Joanna Gemel ; Zihan Su ; Alex Gileles-Hillel ; Abdelnaby Khalyfa…
- 关键词：Intermittent hypoxia ; Obstructive sleep apnea ; Atrial fibrillation ; Gap junctions ; Connexin
- 刊名：BMC Cell Biology
- 出版年：2017
- 出版时间：January 2017
- 年：2017
- 卷：18
- 期：1-supp
- 全文大小：1253KB
- 刊物主题：Cell Biology; Biological Microscopy; Life Sciences, general;
- 出版者：BioMed Central
- ISSN：1471-2121
- 卷排序：18
文摘
BackgroundObstructive sleep apnea has been linked to the development of heart disease and arrhythmias, including atrial fibrillation. Since altered conduction through gap junction channels can contribute to the pathogenesis of such arrhythmias, we examined the abundance and distributions of the major cardiac gap junction proteins, connexin40 (Cx40) and connexin43 (Cx43) in mice treated with sleep fragmentation or intermittent hypoxia (IH) as animal models of the components of obstructive sleep apnea.