Regioselectivity of 1,3-dipolar cycloadditions and antimicrobial activity of isoxazoline, pyrrolo[3,4-d]isoxazole-4,6-diones, pyrazolo[3,4-d]pyridazines and pyrazolo[1,5-a<
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- 作者：Yasser Hassan Zaki ; Abdelwahed Rashad Sayed ; Shaaban A. Elroby
- 关键词：Isoxazoline ; Regioselectivity ; 1 ; 3 ; Dipolar cycloadditions ; Density functional theory ; Pyrrolo[3 ; 4 ; d]isoxazole ; Pyrazoles ; Pyrazolo[3 ; 4 ; d]pyridazines ; Pyrazolo[1 ; 5 ; a]pyrimidine
- 刊名：Chemistry Central Journal
- 出版年：2016
- 出版时间：December 2016
- 年：2016
- 卷：10
- 期：1
- 全文大小：1,454 KB
- 刊物类别：Chemistry and Materials Science
- 出版者：Chemistry Central Ltd
- ISSN：1752-153X
文摘
Background Isoxazoles exhibit interesting biological activities, and the 1,3-dipolar cycloaddition(13DC) reactions play an important role in both mechanistic and synthetic organic chemistry. Pyrazoles and annulated pyrazoles exhibit some diverse biological activities. They are used as antipyretic, analgesic drugs, tranquilizing, and herbicidal agents. Pyrazoles are also used extensively as useful synthons in organic synthesis. Pyrazolo[3,4-d]pyridazines showed good antimicrobial, anti-inflammatory and analgesic activities. Several oximes are found to be hyperglycemic, anti-neoplastic, anti-inflammatory, anti-leishmanial and VEGFR-2 kinase inhibitors.