Clinical, pharmacokinetic and pharmacodynamic evaluations of metronomic UFT and cyclophosphamide plus celecoxib in patients with advanced refractory gastrointestinal cancers

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• 作者：Giacomo Allegrini (1)
  Teresa Di Desidero (2)
  Maria Teresa Barletta (3)
  Anna Fioravanti (2)
  Paola Orlandi (2)
  Bastianina Canu (2)
  Silvio Chericoni (4)
  Fotios Loupakis (3)
  Antonello Di Paolo (2)
  Gianluca Masi (3)
  Andrea Fontana (3)
  Sara Lucchesi (13)
  Giada Arrighi (1)
  Mario Giusiani (4)
  Andrea Ciarlo (5)
  Giovanni Brandi (6)
  Romano Danesi (2)
  Robert S. Kerbel (7)
  Alfredo Falcone (3)
  Guido Bocci (2) guido.bocci@med.unipi.it
• 关键词：Metronomic chemotherapy &#8211 ; Gastrointestinal cancer patients &#8211 ; Angiogenesis &#8211 ; Pharmacodynamic biomarkers &#8211 ; Pharmacokinetics &#8211 ; UFT &#8211 ; Cyclophosphamide &#8211 ; GHB
• 刊名：Angiogenesis
• 出版年：2012
• 出版时间：June 2012
• 年：2012
• 卷：15
• 期：2
• 页码：275-286
• 全文大小：521.2 KB
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• 作者单位：1. Division of Medical Oncology, Azienda USL 5 Pisa, Pontedera, Pisa, Italy2. Division of Pharmacology, Department of Internal Medicine, University of Pisa, Via Roma, 55, 56126 Pisa, Italy3. Department of Oncology, Transplants and New Technologies in Medicine, University of Pisa, Pisa, Italy4. Division of Legal Medicine, Department of Neuroscience, University of Pisa, Pisa, Italy5. U.O. Oncologia Medica Az-USL4, Prato, Italy6. Dipartimento di Ematologia e Scienze Oncologiche L.A. Seragnoli, Universit脿 di Bologna, Policlinico S. Orsola, Bologna, Italy7. Sunnybrook Research Institute, Molecular and Cellular Biology Research, University of Toronto, Toronto, Canada
• 刊物类别：Medicine
• 刊物主题：Medicine & Public Health
  Oncology
  Cancer Research
  Cell Biology
  Cardiology
  Ophthalmology
  
• 出版者：Springer Netherlands
• ISSN：1573-7209

文摘

Aims To evaluate UFT and cyclophosphamide (CTX) based metronomic chemotherapy plus celecoxib (CXB) for the treatment of patients with heavily pre-treated advanced gastrointestinal malignancies.