Expression of a hyaluronic acid-binding proteoglycan (versican) in the cynomolgus monkey eye

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• 作者：Kensuke Tajiri ; Eisuke Isizaki ; Atsuko Nakaizumi…
• 关键词：Hyaluronic acid ; Versican ; Retina ; Ciliary body
• 刊名：International Ophthalmology
• 出版年：2016
• 出版时间：October 2016
• 年：2016
• 卷：36
• 期：5
• 页码：651-656
• 全文大小：772 KB
• 刊物类别：Medicine
• 刊物主题：Medicine & Public Health
  Ophthalmology
  
• 出版者：Springer Netherlands
• ISSN：1573-2630
• 卷排序：36

文摘

The expression of versican, a hyaluronic acid (HA)-binding protein, during the development and differentiation of the retina has been reported. In this study, we performed histochemical and immunohistological analysis of HA and versican from the ciliary body to the retina in cynomolgus monkey eyes. Paraffin-embedded sections of cynomolgus monkey eyes, including from the ciliary body to the macular region, were prepared. The distribution of versican and HA was examined by histochemical and immunohistochemical methods. The sites of HA expression and versican expression in the eye specimens were similar. Expression of HA and versican was observed in the peripheral retina and ciliary body, but not from the macular region to the mid-periphery of the retina. Versican was strongly expressed in the ciliary body, particularly in the non-pigmented ciliary epithelium. Expression in the retina from the periphery to posterior pole gradually decreased. Versican is expressed from the ciliary body to the peripheral retina, but this expression decreases toward the posterior pole. This suggests a physiological function for versican in the peripheral retina.