Triptolide Induces hepatotoxicity via inhibition of CYP450s in Rat liver microsomes

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• 作者：Yan Lu ; Tong Xie ; Yajie Zhang ; Fuqiong Zhou…
• 关键词：CYP450s ; Hepatotoxicity ; Microsomes ; Triptolide
• 刊名：BMC Complementary and Alternative Medicine
• 出版年：2017
• 出版时间：December 2017
• 年：2017
• 卷：17
• 期：1
• 全文大小：4864KB
• 刊物主题：Complementary & Alternative Medicine; Internal Medicine; Chiropractic Medicine;
• 出版者：BioMed Central
• ISSN：1472-6882
• 卷排序：17

文摘

BackgroundTriptolide (TP), an active constituent of Tripterygium wilfordii, possesses numerous pharmacological activities. However, its effects on cytochrome P450 enzymes (CYP450s) in rats remain unexplored.