Candida guilliermondii as a potential biocatalyst for the production of long-chain α,ω-dicarboxylic acids

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• 作者：Nicole Werner ; Miriam Dreyer ; Wenke Wagner ; Nicolas Papon…
• 关键词：Acyl ; CoA oxidase ; Cytochrome P450 hydroxylase ; Genetic engineering ; Long chain dicarboxylic acids ; Oleic acid ; β ; Oxidation ; ω ; Oxidation
• 刊名：Biotechnology Letters
• 出版年：2017
• 出版时间：March 2017
• 年：2017
• 卷：39
• 期：3
• 页码：429-438
• 全文大小：
• 刊物类别：Biomedical and Life Sciences
• 刊物主题：Microbiology; Biotechnology; Applied Microbiology; Biochemistry, general;
• 出版者：Springer Netherlands
• ISSN：1573-6776
• 卷排序：39

文摘

ObjectivesTo explore Candida guilliermondii for the production of long-chain dicarboxylic acids (DCA), we performed metabolic pathway engineering aiming to prevent DCA consumption during β-oxidation, but also to increase its production via the ω-oxidation pathway.