The protective effect of growth hormone on Cu/Zn superoxide dismutase-mutant motor neurons

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• 作者：Jin-Young Chung (1)
  Hyun-Jung Kim (2)
  Manho Kim (2) (3)
  
  1. Department of Veterinary Internal Medicine and Geriatrics ; Kangwon National University ; Gangwondo ; South Korea
  2. Department of Neurology ; Seoul National University Hospital ; 101 Daehakro ; Chongno-ku ; 110-744 ; Seoul ; South Korea
  3. Protein Metabolism Medical Research Center ; College of Medicine ; Seoul National University ; 101 Daehakro ; Chongno-ku ; 110-744 ; Seoul ; South Korea
  
• 关键词：Amyotrophic lateral sclerosis (ALS) ; Growth hormone (GH) ; Mutated SOD1
• 刊名：BMC Neuroscience
• 出版年：2015
• 出版时间：December 2015
• 年：2015
• 卷：16
• 期：1
• 全文大小：2,515 KB
• 参考文献：1. Abe K, Pan LH, Watanabe M, Kato T, Itoyama Y. Induction of nitrotyrosine-like immunoreactivity in the lower motor neuron of amyotrophic lateral sclerosis. Neurosci Lett. 1995;199:152鈥?. CrossRef
  2. Strong MJ. The basic aspects of therapeutics in amyotrophic lateral sclerosis. Pharmacol Ther. 2003;98:379鈥?14. CrossRef
  3. Horton WA, Eldridge R, Brody JA. Familial motor neuron disease: evidence for at least three different types. Neurology. 1976;26:460鈥?. CrossRef
  4. Bruijn LI, Miller TM, Cleveland DW. Unraveling the mechanisms involved in motor neuron degeneration in ALS. Annu Rev Neurosci. 2004;27:723鈥?9. CrossRef
  5. Pasinelli P, Brown RH. Molecular biology of amyotrophic lateral sclerosis: insights from genetics. Nat Rev Neurosci. 2006;7:710鈥?3. CrossRef
  6. Gurney ME, Tomasselli AG, Heinrikson RL. Neurobiology: stay the executioner鈥檚 hand. Science. 2000;288:283鈥?. CrossRef
  7. Brown Jr RH, Robberecht W. Amyotrophic lateral sclerosis: pathogenesis. Semin Neurol. 2001;21:131鈥?. CrossRef
  8. Cleveland DW, Rothstein JD. From Charcot to Lou Gehrig: deciphering selective motor neuron death in ALS. Nat Rev Neurosci. 2001;2:806鈥?9. CrossRef
  9. Sung JJ, Kim HJ, Choi-Kwon S, Lee J, Kim M, Lee KW. Homocysteine induces oxidative cytotoxicity in Cu, Zn-superoxide dismutase mutant motor neuronal cell. Neuroreport. 2002;13:377鈥?1. CrossRef
  10. Zhang F, Slungaard A, Vercellotti GM, Iadecola C. Superoxide-dependent cerebrovascular effects of homocysteine. Am J Physiol. 1998;274:R1704鈥?1.
  11. Choi DW. Calcium and excitotoxic neuronal injury. Ann N Y Acad Sci. 1994;747:162鈥?1. CrossRef
  12. Kim GW, Chan PH. Involvement of superoxide in excitotoxicity and DNA fragmentation in striatal vulnerability in mice after treatment with the mitochondrial toxin, 3-nitropropionic acid. J Cereb Blood Flow Metab. 2002;22:798鈥?09. CrossRef
  13. Moller N, Gjedsted J, Gormsen L, Fuglsang J, Djurhuus C. Effects of growth hormone on lipid metabolism in humans. Growth Horm IGF Res. 2003;13(Suppl A):S18鈥?1. CrossRef
  14. Lyuh E, Kim HJ, Kim M, Lee JK, Park KS, Yoo KY, et al. Dose-specific or dose-dependent effect of growth hormone treatment on the proliferation and differentiation of cultured neuronal cells. Growth Horm IGF Res. 2007;17:315鈥?2. CrossRef
  15. Frago LM, Paneda C, Dickson SL, Hewson AK, Argente J, Chowen JA. Growth hormone (GH) and GH-releasing peptide-6 increase brain insulin-like growth factor-I expression and activate intracellular signaling pathways involved in neuroprotection. Endocrinology. 2002;143:4113鈥?2. CrossRef
  16. Dobrowolny G, Giacinti C, Pelosi L, Nicoletti C, Winn N, Barberi L, et al. Muscle expression of a local Igf-1 isoform protects motor neurons in an ALS mouse model. J Cell Biol. 2005;168:193鈥?. CrossRef
  17. Wilczak N, de Keyser J. Insulin-like growth factor system in amyotrophic lateral sclerosis. Endocr Dev. 2005;9:160鈥?. CrossRef
  18. Barreca T, Muratorio A, Sannia A, Murri L, Rossi B, Rolandi E. Evaluation of twenty-four-hour secretory patterns of growth hormone and insulin in patients with myotonic dystrophy. J Clin Endocrinol Metab. 1980;51:1089鈥?2. CrossRef
  19. Gomez-Saez JM, Fernandez-Real JM, Navarro MA, Martinez-Matos JA, Soler J. GH secretion status in myotonic dystrophy. Psychoneuroendocrinology. 1993;18:183鈥?0. CrossRef
  20. Morselli LL, Bongioanni P, Genovesi M, Licitra R, Rossi B, Murri L, et al. Growth hormone secretion is impaired in amyotrophic lateral sclerosis. Clin Endocrinol (Oxf). 2006;65:385鈥?. CrossRef
  21. Zhang X, Chen S, Li L, Wang Q, Le W. Folic acid protects motor neurons against the increased homocysteine, inflammation and apoptosis in SOD1 G93A transgenic mice. Neuropharmacology. 2008;54:1112鈥?. CrossRef
  22. Park JH, Hong YH, Kim HJ, Kim SM, Kim MJ, Park KS, et al. Pyruvate slows disease progression in a G93A SOD1 mutant transgenic mouse model. Neurosci Lett. 2007;413:265鈥?. CrossRef
  23. Savine R, Sonksen P. Growth hormone - hormone replacement for the somatopause? Horm Res. 2000;53 Suppl 3:37鈥?1. CrossRef
  24. Tollet-Egnell P, Flores-Morales A, Stahlberg N, Malek RL, Lee N, Norstedt G. Gene expression profile of the aging process in rat liver: normalizing effects of growth hormone replacement. Mol Endocrinol. 2001;15:308鈥?8. CrossRef
  25. Tresguerres JA, Kireev R, Tresguerres AF, Borras C, Vara E, Ariznavarreta C. Molecular mechanisms involved in the hormonal prevention of aging in the rat. J Steroid Biochem Mol Biol. 2008;108:318鈥?6. CrossRef
  26. Hanci M, Kuday C, Oguzoglu SA. The effects of synthetic growth hormone on spinal cord injury. J Neurosurg Sci. 1994;38:43鈥?.
  27. Winkler T, Sharma HS, Stalberg E, Badgaiyan RD, Westman J, Nyberg F. Growth hormone attenuates alterations in spinal cord evoked potentials and cell injury following trauma to the rat spinal cord: an experimental study using topical application of rat growth hormone. Amino Acids. 2000;19:363鈥?1. CrossRef
  28. Scheepens A, Sirimanne ES, Breier BH, Clark RG, Gluckman PD, Williams CE. Growth hormone as a neuronal rescue factor during recovery from CNS injury. Neuroscience. 2001;104:677鈥?7. CrossRef
  29. Chen L, Lund PK, Burgess SB, Rudisch BE, McIlwain DL. Growth hormone, insulin-like growth factor I, and motoneuron size. J Neurobiol. 1997;32:202鈥?2. CrossRef
  30. Parsons SA, Banks GB, Rowland JA, Coschigano KT, Kopchick JJ, Waters MJ, et al. Genetic disruption of the growth hormone receptor does not influence motoneuron survival in the developing mouse. Int J Dev Biol. 2003;47:41鈥?.
  31. Bilic E, Rudan I, Kusec V, Zurak N, Delimar D, Zagar M. Comparison of the growth hormone, IGF-1 and insulin in cerebrospinal fluid and serum between patients with motor neuron disease and healthy controls. Eur J Neurol. 2006;13:1340鈥?. CrossRef
  32. Morselli LL, Bongioanni P, Genovesi M, Licitra R, Rossi B, Murri L, et al. Impairment of GH secretion in amyotrophic lateral sclerosis is not affected by riluzole treatment. J Endocrinol Invest. 2007;30:767鈥?0. CrossRef
  33. Pellecchia MT, Pivonello R, Monsurro MR, Trojsi F, Longo K, Piccirillo G, et al. The GH-IGF system in amyotrophic lateral sclerosis: correlations between pituitary GH secretion capacity, insulin-like growth factors and clinical features. Eur J Neurol. 2010;17:666鈥?1. CrossRef
  34. Sacca F, Quarantelli M, Rinaldi C, Tucci T, Piro R, Perrotta G, et al. A randomized controlled clinical trial of growth hormone in amyotrophic lateral sclerosis: clinical, neuroimaging, and hormonal results. J Neurol. 2012;259:132鈥?. CrossRef
  35. Sorenson EJ, Windbank AJ, Mandrekar JN, Bamlet WR, Appel SH, Armon C, et al. Subcutaneous IGF-1 is not beneficial in 2-year ALS trial. Neurology. 2008;71:1770鈥?. CrossRef
  36. Kim HJ, Kim M, Kim SH, Sung JJ, Lee KW. Alteration in intracellular calcium homeostasis reduces motor neuronal viability expressing mutated Cu/Zn superoxide dismutase through a nitric oxide/guanylyl cyclase cGMP cascade. Neuroreport. 2002;13:1131鈥?. CrossRef
  37. Chung YH, Hong JJ, Shin CM, Joo KM, Kim MJ, Cha CI. Immunohistochemical study on the distribution of homocysteine in the central nervous system of transgenic mice expressing a human Cu/Zn SOD mutation. Brain Res. 2003;967:226鈥?4. CrossRef
  38. Guegan C, Vila M, Rosoklija G, Hays AP, Przedborski S. Recruitment of the mitochondrial-dependent apoptotic pathway in amyotrophic lateral sclerosis. J Neurosci. 2001;21:6569鈥?6.
  39. Kroemer G, Reed JC. Mitochondrial control of cell death. Nat Med. 2000;6:513鈥?. CrossRef
  40. Pasinelli P, Houseweart MK, Brown Jr RH, Cleveland DW. Caspase-1 and -3 are sequentially activated in motor neuron death in Cu, Zn superoxide dismutase-mediated familial amyotrophic lateral sclerosis. Proc Natl Acad Sci U S A. 2000;97:13901鈥?. CrossRef
  41. Dolcet X, Soler RM, Gould TW, Egea J, Oppenheim RW, Comella JX. Cytokines promote motoneuron survival through the Janus kinase-dependent activation of the phosphatidylinositol 3-kinase pathway. Mol Cell Neurosci. 2001;18:619鈥?1. CrossRef
  42. Jeay S, Sonenshein GE, Postel-Vinay MC, Kelly PA, Baixeras E. Growth hormone can act as a cytokine controlling survival and proliferation of immune cells: new insights into signaling pathways. Mol Cell Endocrinol. 2002;188:1鈥?. CrossRef
  43. Heiman-Patterson TD, Deitch JS, Blankenhorn EP, Erwin KL, Perreault MJ, Alexander BK, et al. Background and gender effects on survival in the TgN(SOD1-G93A)1Gur mouse model of ALS. J Neurol Sci. 2005;236:1鈥?. CrossRef
  44. Vukosavic S, Dubois-Dauphin M, Romero N, Przedborski S. Bax and Bcl-2 interaction in a transgenic mouse model of familial amyotrophic lateral sclerosis. J Neurochem. 1999;73:2460鈥?. CrossRef
  45. Ekegren T, Grundstrom E, Lindholm D, Aquilonius SM. Upregulation of Bax protein and increased DNA degradation in ALS spinal cord motor neurons. Acta Neurol Scand. 1999;100:317鈥?1. CrossRef
  46. Kim HJ, Im W, Kim S, Kim SH, Sung JJ, Kim M, et al. Calcium-influx increases SOD1 aggregates via nitric oxide in cultured motor neurons. Exp Mol Med. 2007;39:574鈥?2. CrossRef
  47. Kim SH, Kim HJ, Kim M, Lee KW. The effect of calcium modulators on motoneuron cells which express mutated Cu / Zn superoxide dismutase. J Korean Neurol Assoc. 2003;21:521鈥?.
  48. Lee KW, Kim HJ, Sung JJ, Park KS, Kim M. Defective neurite outgrowth in aphidicolin/cAMP-induced motor neurons expressing mutant Cu/Zn superoxide dismutase. Int J Dev Neurosci. 2002;20:521鈥?. CrossRef
  49. Smith RG, Alexianu ME, Crawford G, Nyormoi O, Stefani E, Appel SH. Cytotoxicity of immunoglobulins from amyotrophic lateral sclerosis patients on a hybrid motoneuron cell line. Proc Natl Acad Sci U S A. 1994;91:3393鈥?. CrossRef
  50. Telford WG, King LE, Fraker PJ. Comparative evaluation of several DNA binding dyes in the detection of apoptosis-associated chromatin degradation by flow cytometry. Cytometry. 1992;13:137鈥?3. CrossRef
  51. Gurney ME, Pu H, Chiu AY, Dal Canto MC, Polchow CY, Alexander DD, et al. Motor neuron degeneration in mice that express a human Cu, Zn superoxide dismutase mutation. Science. 1994;264:1772鈥?. CrossRef
  52. Crow JP, Calingasan NY, Chen J, Hill JL, Beal MF. Manganese porphyrin given at symptom onset markedly extends survival of ALS mice. Ann Neurol. 2005;58:258鈥?5. CrossRef
  53. Koh SH, Lee SM, Kim HY, Lee KY, Lee YJ, Kim HT, et al. The effect of epigallocatechin gallate on suppressing disease progression of ALS model mice. Neurosci Lett. 2006;395:103鈥?. CrossRef
  54. Weydt P, Hong SY, Kliot M, Moller T. Assessing disease onset and progression in the SOD1 mouse model of ALS. Neuroreport. 2003;14:1051鈥?.
  
• 刊物主题：Neurosciences; Neurobiology; Animal Models;
• 出版者：BioMed Central
• ISSN：1471-2202

文摘

Background Amyotrophic lateral sclerosis (ALS) is characterized by selective degeneration of motor neurons. The gene encoding Cu/Zn superoxide dismutase (SOD1) is responsible for 20% of familial ALS cases. Growth hormone (GH) concentrations are low in the cerebrospinal fluid of patients with ALS; however, its association with motoneuronal death is not known. We tested the neuroprotective effects of GH on human SOD-1-expressing cultured motor neurons and SOD1G93A transgenic mice. Results In cultured motor neurons, cytotoxicity was induced by A23187, GNSO, or homocysteine, and the effects of GH were determined by MTT, bax, PARP cleavage pattern, Hoechst nuclear staining, MAPK, and PI3K assay. In SOD-1 transgenic mice, rotarod motor performance was evaluated. Survival analysis of motoneuronal loss was done using cresyl violet, GFAP, and Bcl-2 staining. GH prevents motorneuronal death caused by GSNO and homocysteine, but not that by A23187. It activates MAPK and PI3K. GH-treated mice showed prolonged survival with improved motor performance and weight loss. GH decreased cresyl violet positive motoneuronal loss with strong Bcl-2 and less GFAP immunoreactivity. Conclusions Our results demonstrate that GH has a protective effect on mutant SOD-1-expressing motor neurons.