Effects of duodeno-jejunal bypass on glucose metabolism in obese rats with type 2 diabetes

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• 作者：Hirofumi Imoto (1)
  Chikashi Shibata (1)
  Fumie Ikezawa (1)
  Daisuke Kikuchi (1)
  Soutoku Someya (1)
  Koh Miura (1)
  Takeshi Naitoh (1)
  Michiaki Unno (1)
  
• 关键词：Duodeno ; jejunal bypass ; Glucagon ; like peptide ; 1 ; Peptide YY
• 刊名：Surgery Today
• 出版年：2014
• 出版时间：February 2014
• 年：2014
• 卷：44
• 期：2
• 页码：340-348
• 全文大小：649 KB
• 作者单位：Hirofumi Imoto (1)
  Chikashi Shibata (1)
  Fumie Ikezawa (1)
  Daisuke Kikuchi (1)
  Soutoku Someya (1)
  Koh Miura (1)
  Takeshi Naitoh (1)
  Michiaki Unno (1)
  
  1. Division of Biological Regulation and Oncology, Department of Surgery, Tohoku University Graduate School of Medicine, 1-1 Seiryo-machi, Aoba-ku, Sendai, 980-8574, Japan
  
• ISSN：1436-2813

文摘

Purpose To evaluate the foregut and hindgut hypotheses for metabolic surgery in obese rats with diabetes. Methods Otsuka Long-Evans Tokushima fatty rats were divided into a sham operation group, a partial duodeno-jejunal bypass (P-DJB) group, and a complete DJB (C-DJB) group. P-DJB is a model to test foregut hypothesis, whereas C-DJB is a model to test both hypotheses. We performed oral glucose tolerance tests (OGTT) on all groups at baseline, and then 4 and 8?weeks postoperatively. The rats were killed thereafter and the plasma levels of glucagon-like peptide-1 (GLP-1) and peptide YY (PYY) were measured. A separate sub-group of C-DJB rats underwent OGTT after treatment with the GLP-1 antagonist, the PYY antagonist, or saline. Results Marked improvement of the blood glucose control during the OGTT was noted 8?weeks after C-DJB, but not 8?weeks after P-DJB or the sham operation. The serum GLP-1 and PYY levels were higher in the C-DJB group than in the other two groups. Pretreatment with the GLP-1 antagonist increased the blood glucose levels 30?min after the OGTT in the C-DJB rats. Conclusions Improvement in glucose metabolism after DJB was associated with the inflow of bile and pancreatic juice into the ileum, supporting validity of the hindgut hypothesis. GLP-1 appears to play a role in this improvement.