Evaluation of the risk of liver damage from the use of 5-aminolevulinic acid for intra-operative identification and resection in patients with malignant gliomas

详细信息    查看全文

• 作者：Cecilie Mørck Offersen ; Jane Skjoeth-Rasmussen
• 关键词：5 ; ALA ; Glioma ; ALAT ; Liver damage ; Liver enzymes
• 刊名：Acta Neurochirurgica
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：159
• 期：1
• 页码：145-150
• 全文大小：
• 刊物主题：Neurosurgery; Interventional Radiology; Neuroradiology; Neurology; Surgical Orthopedics; Minimally Invasive Surgery;
• 出版者：Springer Vienna
• ISSN：0942-0940
• 卷排序：159

文摘

BackgroundThe clinical efficacy of 5-aminolevulinic acid (5-ALA) for fluorescence-guided surgery of malignant gliomas is evident from several studies; however, as post-operative elevations of liver enzymes have been seen, there is a potential risk of liver damage upon administration. The aim of the present study was to assess the potential risk of liver damage and investigate liver enzyme reactions of patients going through 5-ALA-guided operations to improve the monitoring of their operations.