Nonalcoholic fatty liver disease: one entity, multiple impacts on liver health

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• 作者：Carmen Fierbinteanu-Braticevici ; Crina Sinescu…
• 关键词：Nonalcoholic fatty liver disease ; Fatty liver ; Nonalcoholic steatohepatitis ; Liver fibrosis ; Liver cirrhosis ; Disease progression
• 刊名：Cell Biology and Toxicology
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：33
• 期：1
• 页码：5-14
• 全文大小：
• 刊物类别：Biomedical and Life Sciences
• 刊物主题：Cell Biology; Pharmacology/Toxicology; Biochemistry, general;
• 出版者：Springer Netherlands
• ISSN：1573-6822
• 卷排序：33

文摘

Nonalcoholic fatty liver disease (NAFLD) is very prevalent and now considered the most common cause of chronic liver disease. Staging the severity of liver damage is very important because the prognosis of NAFLD is highly variable. The long-term prognosis of patients with NAFLD remains incompletely elucidated. Even though the annual fibrosis progression rate is significantly higher in patients with nonalcoholic hepatitis (NASH), both types of NAFLD (nonalcoholic fatty liver and nonalcoholic steatohepatitis) can lead to fibrosis. The risk for progressive liver damage and poor outcomes is assessed by staging the severity of liver injury and liver fibrosis. Algorithms (scores) that incorporate various standard clinical and laboratory parameters alongside imaging-based approaches that assess liver stiffness are helpful in predicting advanced fibrosis.