Breast-feeding the last born child and risk of ovarian cancer

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• 作者：Linda Titus-Ernstoff ; Judy R. Rees ; Kathryn L. Terry and Daniel W. Cramer
• 关键词：Ovarian cancer ; Breast ; feeding ; Parity
• 刊名：Cancer Causes and Control
• 出版年：2010
• 出版时间：February, 2010
• 年：2010
• 卷：21
• 期：2
• 页码：201-207
• 全文大小：161.8 KB

文摘

Conflicting reports regarding the relationship between breast-feeding and ovarian cancer risk suggest a possible influence of patterns of breast-feeding. We used logistic regression to examine breast-feeding in a large population of parous women who participated in a case–control study of ovarian cancer in New Hampshire and MA, USA. Risk of ovarian cancer was reduced in parous women who ever breast-fed (OR: 0.75; 95 % CI: 0.62, 0.92), but evidence was limited for an influence of duration of breast-feeding and the number of children breast-fed. Compared to never breast-feeding, inverse associations were seen for breast-feeding all children (OR: 0.72; 95 % CI: 0.58, 0.91) and for breast-feeding some children when the last born child was breast-fed (OR: 0.58; 95 % CI: 0.37, 0.91). There was little evidence of reduced risk for those who breast-fed some children when the last born child was not breast-fed (OR: 0.91; 95 % CI: 0.66, 1.26). Similar findings were noted in women with exactly two children and in those with two or more children. The protective influence of breast-feeding on ovarian cancer risk may be limited to women who breast-feed their last born child. These findings, which require confirmation by future studies, imply that breast-feeding resets pregnancy-related states that mediate ovarian cancer risk.