Methylation levels at IGF2 and GNAS DMRs in infants born to preeclamptic pregnancies

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• 作者：Jing He (10)
  Aiping Zhang (11)
  Min Fang (12)
  Rong Fang (10)
  Jiamei Ge (11)
  Yuan Jiang (12)
  Hong Zhang (10)
  Cong Han (10)
  Xiaoqun Ye (10)
  Danqing Yu (10)
  Hefeng Huang (10) (12)
  Yun Liu (10) (11)
  Minyue Dong (10) (12)
  
• 关键词：Preeclampsia ; Offspring ; DNA methylation ; IGF2 ; GNAS ; Metabolic diseases
• 刊名：BMC Genomics
• 出版年：2013
• 出版时间：December 2013
• 年：2013
• 卷：14
• 期：1
• 全文大小：263KB
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• 作者单位：Jing He (10)
  Aiping Zhang (11)
  Min Fang (12)
  Rong Fang (10)
  Jiamei Ge (11)
  Yuan Jiang (12)
  Hong Zhang (10)
  Cong Han (10)
  Xiaoqun Ye (10)
  Danqing Yu (10)
  Hefeng Huang (10) (12)
  Yun Liu (10) (11)
  Minyue Dong (10) (12)
  
  10. Institutes of Biomedical Sciences, Fudan University, Shanghai, China
  11. Department of Biochemistry and Molecular Biology, Key Laboratory of Molecular Medicine, the Ministry of Education, Fudan University Shanghai Medical College, Add: 303 Mingdao Building, 138 Yixueyuan Road, Shanghai, 200032, PR China
  12. Key Laboratory of Reproductive Genetics, Ministry of Education, Zhejiang University, Hangzhou, China
  

文摘

Background Offspring of pregnancy complicated with preeclampsia are at high risk for hypertension, stroke and possibly obesity. The mechanisms behind the association of intrauterine exposure to preeclampsia and high risk of health problems in the later life remain largely unknown. The aims of the current investigation were to determine the changes in DNA methylation at IGF2 and GNAS DMR in offspring of preeclamptic pregnancy and to explore the possible mechanisms underlying the association between maternal preeclampsia and high risk for health problems in the later life of their offspring. Results Umbilical cord blood was taken from infants born to women of preeclampsia (n=56), gestational hypertension (n=23) and normal pregnancy (n=81). DNA methylation levels of IGF2 and GNAS DMR were determined by Massarray quantitative methylation analysis. Methylation levels at IGF2 DMR were significantly lower in preeclampsia than normal pregnancy. The average methylation level at IGF2 DMR was significantly correlated with preeclampsia even after birth weight, maternal age, gestational age at delivery and fetal gender were adjusted. The difference in methylation level was not significantly different between mild and severe preeclampsia. The methylation level at GNAS DMR was not significantly correlated with birth weight, maternal age, gestational age at delivery, fetal gender, preeclampsia or gestational hypertension. Conclusions We concluded preeclampsia induced a decrease in methylation level at IGF 2 DMR, and this might be among the mechanisms behind the association between intrauterine exposure to preeclampsia and high risk for metabolic diseases in the later life of the infants.