Remineralization of initial enamel caries in vitro using a novel peptide based on amelogenin

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• 作者：Danxue Li ; Xueping Lv ; Huanxin Tu ; Xuedong Zhou…
• 关键词：dental caries ; peptide ; remineralization
• 刊名：Frontiers of Materials Science
• 出版年：2015
• 出版时间：September 2015
• 年：2015
• 卷：9
• 期：3
• 页码：293-302
• 全文大小：5,095 KB
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• 作者单位：Danxue Li (1)
  Xueping Lv (1)
  Huanxin Tu (1)
  Xuedong Zhou (1)
  Haiyang Yu (1)
  Linglin Zhang (1)
  
  1. State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, 610041, China
  
• 刊物类别：Chemistry and Materials Science
• 刊物主题：Materials Science
  Chemistry
  Chinese Library of Science
  
• 出版者：Higher Education Press, co-published with Springer-Verlag GmbH
• ISSN：2095-0268

文摘

Dental caries is the most common oral disease with high incidence, widely spread and can seriously affect the health of oral cavity and the whole body. Current caries prevention measures such as fluoride treatment, antimicrobial agents, and traditional Chinese herbal, have limitations to some extent. Here we design and synthesize a novel peptide based on the amelogenin, and assess its ability to promote the remineralization of initial enamel caries lesions. We used enamel blocks to form initial lesions, and then subjected to 12-day pH cycling in the presence of peptide, NaF and HEPES buffer. Enamel treated with peptide or NaF had shallower, narrower lesions, thicker remineralized surfaces and less mineral loss than enamel treated with HEPES. This peptide can promote the remineralization of initial enamel caries and inhibit the progress of caries. It is a promising anti-caries agent with various research prospects and practical application value.