Pruritus and Atopic Dermatitis

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• 作者：Ulf Darsow (1) (2) (3) (6)
  Florian Pfab (1) (2) (3)
  Michael Valet (4)
  Johannes Huss-Marp (2)
  Heidrun Behrendt (2) (3)
  Johannes Ring (1) (3)
  Sonja St?nder (5)
  
• 关键词：Atopic dermatitis ; Eczema ; Itch ; Antipruritic treatment
• 刊名：Clinical Reviews in Allergy & Immunology
• 出版年：2011
• 出版时间：December 2011
• 年：2011
• 卷：41
• 期：3
• 页码：237-244
• 全文大小：277KB
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• 作者单位：Ulf Darsow (1) (2) (3) (6)
  Florian Pfab (1) (2) (3)
  Michael Valet (4)
  Johannes Huss-Marp (2)
  Heidrun Behrendt (2) (3)
  Johannes Ring (1) (3)
  Sonja St?nder (5)
  
  1. Department of Dermatology and Allergy Biederstein, Technische Universit?t München, Munich, Germany
  2. Division of Environmental Dermatology and Allergy GSF/TUM, Munich, Germany
  3. Christine Kühne Center for Allergy Research and Education (CK-CARE), Munich, Germany
  6. Klinik und Poliklinik für Dermatologie und Allergologie am Biederstein, Technische Universit?t München, Biedersteiner Str. 29, 80802, Munich, Germany
  4. Department of Neurology, Technische Universit?t München, Munich, Germany
  5. Department of Dermatology, Competence Center Pruritus, University of Münster, Münster, Germany
  
• ISSN：1559-0267

文摘

Atopic eczema is one of the most pruritic skin diseases. Mediators of atopic eczema itch in the skin are still mostly unknown, but recent studies showed that the histamine 4 receptor plays an important role in itch pathophysiology; tryptase and interleukin-31 are also involved. Differences in itch perception and itch kinetics between healthy volunteers and eczema patients point towards an ongoing central nervous inhibitory activity in patients. Questionnaire studies reported comparatively higher loads in affective items chosen by patients with atopic eczema. In the concept of patient management, the therapy of clinical pruritus has to consider origin and perception of itch, namely the skin and the central nervous system, by combining topical and systemic treatment.