Stepped wedge randomised controlled trials: systematic review of studies published between 2010 and 2014
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- 作者：Emma Beard ; James J. Lewis ; Andrew Copas ; Calum Davey ; David Osrin ; Gianluca Baio…
- 关键词：Stepped wedge trials ; Systematic review ; Methodology ; Public health
- 刊名：Trials
- 出版年：2015
- 出版时间：December 2015
- 年：2015
- 卷：16
- 期：1
- 全文大小：601 KB
- 刊物主题：Medicine/Public Health, general; Biomedicine general; Statistics for Life Sciences, Medicine, Health Sciences;
- 出版者：BioMed Central
- ISSN：1745-6215
文摘
Background In a stepped wedge, cluster randomised trial, clusters receive the intervention at different time points, and the order in which they received it is randomised. Previous systematic reviews of stepped wedge trials have documented a steady rise in their use between 1987 and 2010, which was attributed to the design’s perceived logistical and analytical advantages. However, the interventions included in these systematic reviews were often poorly reported and did not adequately describe the analysis and/or methodology used. Since 2010, a number of additional stepped wedge trials have been published. This article aims to update previous systematic reviews, and consider what interventions were tested and the rationale given for using a stepped wedge design.