Age-related peculiarities of change in content of free radical oxidation products in muscle during stress

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• 作者：Vadim V. Davydov (1)
  Amjad Hamdallah (2)
  Evgenya R. Grabovetskaya (3)
  
• 关键词：ontogenesis ; stress ; skeletal muscle ; free radical oxidation
• 刊名：Frontiers in Biology
• 出版年：2014
• 出版时间：August 2014
• 年：2014
• 卷：9
• 期：4
• 页码：283-286
• 全文大小：130 KB
• 参考文献：1. Boirie Y (2009). Physiopathological mechanism of sarcopenia. J Nutr Health Aging, 13(8): 717鈥?23 CrossRef
  2. Calvani R, Joseph A M, Adhihetty P J, Miccheli A, Bossola M, Leeuwenburgh C, Bernabei R, Marzetti E (2013). Mitochondrial pathways in sarcopenia of aging and disuse muscle atrophy. Biol Chem, 394(3): 393鈥?14 CrossRef
  3. Chen C N, Brown-Borg H M, Rakoczy S G, Thompson L V (2008). Muscle disuse: adaptation of antioxidant systems is age dependent. J Gerontol A Biol Sci Med Sci, 63(5): 461鈥?66 CrossRef
  4. Czarkowska-Paczek B, Milczarczyk S (2006). [Age-related muscle mass loss]. Przegl Lek, 63(8): 658鈥?61
  5. Davydov V V, Bozhkov A I, Kulchitski O K (2012). Physiological and pathophysiological role of endogenous aldehydes. Saarbrucken: Palmarium Academic Publishing, 240 (in Russian)
  6. Davydov V V, Dobaeva N M, Bozhkov A I (2004). Possible role of alteration of aldehyde鈥檚 scavenger enzymes during aging. Exp Gerontol, 39(1): 11鈥?6 CrossRef
  7. Davydov V V, Shvets V N (2003). Age-dependent differences in the stimulation of lipid peroxidation in the heart of rats during immobilization stress. Exp Gerontol, 38(6): 693鈥?98 CrossRef
  8. Esterbauer H, Zollner H (1989). Methods for determination of aldehydic lipid peroxidation products. Free Radic Biol Med, 7(2): 197鈥?03 CrossRef
  9. Fagan J M, Sleczka B G, Sohar I (1999). Quantitation of oxidative damage to tissue proteins. Int J Biochem Cell Biol, 31(7): 751鈥?57 CrossRef
  10. Frontera W R, Zayas A R, Rodriguez N (2012). Aging of human muscle: understanding sarcopenia at the single muscle cell level. Phys Med Rehabil Clin N Am, 23(1): 201鈥?07 CrossRef
  11. Gianni P, Jan K J, Douglas M J, Stuart P M, Tarnopolsky M A (2004). Oxidative stress and the mitochondrial theory of aging in human skeletal muscle. Exp Gerontol, 39(9): 1391鈥?400 CrossRef
  12. Hindle A G, Lawler J M, Campbell K L, Horning M (2010). Muscle aging and oxidative stress in wild-caught shrews. Comp Biochem Physiol B Biochem Mol Biol, 155(4): 427鈥?34 CrossRef
  13. Jackson M J (2009). Skeletal muscle aging: role of reactive oxygen species. Crit Care Med, 37(10 Suppl): S368鈥揝371 CrossRef
  14. Madsen K, Ertbjerg P, Djurhuus M S, Pedersen P K (1996). Calcium content and respiratory control index of skeletal muscle mitochondria during exercise and recovery. Am J Physiol, 271(6 Pt 1): E1044鈥揈1050
  15. Meerson F Z (1984). Pathogenesis and prevention of stress and ischemic injures of heart. Moscow: Medicina (B Aires), 270 (in Russian)
  16. Narici M V, Maffulli N (2010). Sarcopenia: characteristics, mechanisms and functional significance. Br Med Bull, 95(1): 139鈥?59 CrossRef
  17. Rossi P, Marzani B, Giardina S, Negro M, Marzatico F (2008). Human skeletal muscle aging and the oxidative system: cellular events. Curr Aging Sci, 1(3): 182鈥?91 CrossRef
  
• 作者单位：Vadim V. Davydov (1)
  Amjad Hamdallah (2)
  Evgenya R. Grabovetskaya (3)
  
  1. Laboratory of Age Biochemistry State Institution Institute of Children and Adolescent Health NAMS of Ukraine, Kharkov, 61154, Ukraine
  2. Chair of biochemistry V.N. Karazin Kharkov National University, Kharkov, 61077, Ukraine
  3. Chair of medical chemistry Kharkov National Medical University, Kharkov, 61022, Ukraine
  
• ISSN：1674-7992

文摘

The age-dependent peculiarities of stimulation of free radical processes in subcellular fractions of skeletal muscle of rats subjected to long-term immobilization stress were studied in order to improve knowledge about changes of muscular tissue during ontogenesis. It is found that adult animals do not show accumulation of proteins carbonyls, TBA-reactive substances, and Schiff bases in subcellular fractions of the thigh muscle when immobilized. Long-term immobilization causes apparent manifestation of oxidative stress only in mitochondrial fraction in pubertal rats. Mitochondrial oxidative stress defense systems are sufficiently effective, however, direction of pathways of free radical oxidation carbonyl products catabolism alters in the cytoplasm of myocytes in old rats under long-term immobilization conditions.