Age-dependent peculiarities modulation of activity of aldehyde scavenger enzymes in mitochondria of rat thigh muscle during stress

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• 作者：Vadim V. Davydov ; Evgenya R. Grabovetskaya ; Amjad Hamdallah
• 关键词：aldehydes ; mitochondria ; muscle ; immobilization stress ; aging
• 刊名：Frontiers in Biology
• 出版年：2016
• 出版时间：February 2016
• 年：2016
• 卷：11
• 期：1
• 页码：28-31
• 全文大小：106 KB
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• 作者单位：Vadim V. Davydov (1)
  Evgenya R. Grabovetskaya (2)
  Amjad Hamdallah (3)
  
  1. Chair of Biochemistry State Academican I.P.Pavlov Medical University, Ryazan, 390026, Russia
  2. Chair of Medical Chemistry Kharkov National Medical University, Kharkov, 61022, Ukraine
  3. Chair of Biochemistry V.N. Karazin Kharkov National University, Kharkov, 61077, Ukraine
  
• 刊物主题：Proteomics; Neurobiology; Genetics and Population Dynamics; Developmental Biology; Biochemistry, general; Cell Biology;
• 出版者：Springer Berlin Heidelberg
• ISSN：1674-7992

文摘

The purpose of this study was a comparative investigation of activity of aldehyde scavenger enzymes in mitochondrial fraction of a thigh muscle in intact and immobilized rats of different ages. It has been shown that 12-month-old (adult) rats have high basal levels of aldehyde dehydrogenase, aldehyde reductase and glutathione transferase activity in mitochondrial fraction of thigh muscle. Aldehyde dehydrogenase activity increases during immobilization stress in adult rats. This change promote to enhance the effectiveness of utilization of carbonyl products of free radical oxidation in mitochondria of skeletal muscle of 12-month-old rats during stress. Immobilization of old and pubertal rats is accompanied by metabolic preconditions leading to accumulation of endogenous aldehydes in mitochondria, and, as a result, to the injury of muscular fibers and intensification of sarcopenia manifestations.