Synthesis and antimicrobial activity of novel mancozeb derivatives containing 1,3,4-thiadiazole

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• 作者：Yuting Liu ; Gangtao Liang ; Dawei Yin
• 关键词：Mancozeb ; 1 ; 3 ; 4 ; Thiadiazole ; Synthesis ; Antimicrobial activity
• 刊名：Research on Chemical Intermediates
• 出版年：2015
• 出版时间：April 2015
• 年：2015
• 卷：41
• 期：4
• 页码：2019-2024
• 全文大小：210 KB
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• 刊物类别：Chemistry and Materials Science
• 刊物主题：Chemistry
  Catalysis
  Physical Chemistry
  Inorganic Chemistry
  
• 出版者：Springer Netherlands
• ISSN：1568-5675

文摘

Four mancozeb derivatives containing 1,3,4-thiadiazole, 5a-strong class="a-plus-plus">5d, were successfully synthesized, then characterized by IR, 1H NMR, and 13C NMR spectroscopy and elemental analysis. Their antimicrobial activity against paddy fusarium, Botrytis cinerea, cucumber fusarium, tomato gibberella, and grape white rot was tested in vitro by use of the filter paper disk-diffusion technique. Compounds 5a-strong class="a-plus-plus">5d had moderate to excellent antimicrobial activity in comparison with mancozeb, 6. Among these compounds, 5a had the best inhibitory activity.