Effect of estrogen deficiency on the fixation of titanium implants in chronic kidney disease mice

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• 作者：S. Zhang (1)
  Y. Guo (1)
  H. Zou (2)
  N. Sun (1)
  D. Zhao (1)
  W. Liu (1)
  Y. Dong (1)
  G. Cheng (3)
  Q. Yuan (1)
  
  1. State Key Laboratory of Oral Diseases ; West China Hospital of Stomatology ; Sichuan University ; 14 Third Section ; Renmin Nan Road ; 610041 ; Chengdu ; China
  2. Chongqing Key Laboratory for Oral Diseases and Biomedical Sciences ; The Affiliated Hospital of Stomatology ; Chongqing Medical University ; Chengdu ; China
  3. Department of Nutrition ; Food Safety and Toxicology ; West China School of Public Health ; Sichuan University ; Chengdu ; China
  
• 关键词：Chronic kidney disease ; Estrogen deficiency ; Osseointegration ; Titanium implants
• 刊名：Osteoporosis International
• 出版年：2015
• 出版时间：March 2015
• 年：2015
• 卷：26
• 期：3
• 页码：1073-1080
• 全文大小：776 KB
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• 刊物类别：Medicine
• 刊物主题：Medicine & Public Health
  Orthopedics
  Gynecology
  Endocrinology
  Rheumatology
  
• 出版者：Springer London
• ISSN：1433-2965

文摘

Summary We established a chronic kidney disease (CKD) mouse model with estrogen deficiency and inserted titanium implants into the femur of such mice to investigate the fixation of the implants. Both the histomorphometry and implant resistance indicated that estrogen deficiency impaired the fixation of titanium implants inserted into such mice. Introduction CKD has been regarded as a worldwide public health problem. Estrogen is a critical factor for both renal protection and bone remodeling. A previous study demonstrated that CKD impairs the early healing of titanium implants. However, the combined effect of estrogen deficiency and CKD on the fixation of titanium implants is largely unknown. Methods Forty 9-week-old female C57BL mice were randomly divided into sham, ovariectomy (OVX), CKD, and CKD + OVX groups. Uremia and estrogen deficiency were induced by 5/6 nephrectomy and OVX, respectively. Experimental titanium implants were inserted into the distal end of the femur. Bone-implant contact (BIC) ratio and bone volume (BV/TV) around the implants were histomorphometrically analyzed. The fixation strength of the implant was measured by a biomechanical push-in resistance test. Results Serum measurement confirmed a significant increase in serum blood urea nitrogen (BUN) in the CKD group, which was further increased by OVX. Estrogen deficiency led to significant decreases in the BIC ratio, BV/TV, and the push-in resistance in CKD animals. There was a significant interaction between the effects of OVX and CKD, with OVX exacerbating the effects of CKD on BIC ratio and push-in resistance. Conclusions The results indicated that estrogen deficiency exerts a synergistic effect with CKD and further impairs the fixation of titanium implants in CKD mice.