Marrow adipogenesis and bone loss that parallels estrogen deficiency is slowed by low-intensity mechanical signals

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• 作者：D. Krishnamoorthy ; D. M. Frechette ; B. J. Adler ; D. E. Green…
• 关键词：Adipocyte ; Bone marrow ; Exercise ; Mechanical ; Obesity ; Osteoporosis ; Postmenopausal
• 刊名：Osteoporosis International
• 出版年：2016
• 出版时间：February 2016
• 年：2016
• 卷：27
• 期：2
• 页码：747-756
• 全文大小：2,436 KB
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• 作者单位：D. Krishnamoorthy (1)
  D. M. Frechette (1)
  B. J. Adler (1)
  D. E. Green (1)
  M. E. Chan (1)
  C. T. Rubin (1)
  
  1. Department of Biomedical Engineering, Stony Brook University, Stony Brook, NY, USA
  
• 刊物类别：Medicine
• 刊物主题：Medicine & Public Health
  Orthopedics
  Gynecology
  Endocrinology
  Rheumatology
  
• 出版者：Springer London
• ISSN：1433-2965

文摘

Summary Ovariectomized mice were used to assess the ability of low-intensity vibrations to protect bone microarchitecture and marrow composition. Results indicate that low-intensity vibrations (LIV), introduced 2 weeks postsurgery, slows marrow adipogenesis in OVX mice but does not restore the bone within the period studied. However, immediate application of LIV partially protects quality.