Serum total estradiol, but not testosterone is associated with reduced bone mineral density (BMD) in HIV-infected men: a cross-sectional, observational study

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• 作者：D. Santi ; B. Madeo ; F. Carli ; S. Zona ; G. Brigante…
• 关键词：BMD ; Estradiol ; HIV ; Testosterone
• 刊名：Osteoporosis International
• 出版年：2016
• 出版时间：March 2016
• 年：2016
• 卷：27
• 期：3
• 页码：1103-1114
• 全文大小：679 KB
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• 作者单位：D. Santi (1) (2)
  B. Madeo (2)
  F. Carli (3)
  S. Zona (3)
  G. Brigante (1)
  F. Vescini (4)
  G. Guaraldi (3)
  V. Rochira (1) (2)
  
  1. Unit of Endocrinology, Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, Via P. Giardini 1355, 41126, Modena, Italy
  2. Azienda USL of Modena, NOCSAE, Via P. Giardini 1355, 41126, Modena, Italy
  3. Metabolic Clinic, Infectious and Tropical Disease Unit, Department of Medical and Surgical Sciences for Adults and Children, Clinic of Infectious Diseases, University of Modena and Reggio Emilia, Via del Pozzo 71, 41124, Modena, Italy
  4. Endocrinology and Metabolism Unit, University-Hospital S. Maria della Misericordia of Udine, P.za S. Maria della Misericordia 15, 33100, Udine, Italy
  
• 刊物类别：Medicine
• 刊物主题：Medicine & Public Health
  Orthopedics
  Gynecology
  Endocrinology
  Rheumatology
  
• 出版者：Springer London
• ISSN：1433-2965

文摘

Summary By investigating the relationship between serum testosterone, estradiol, and bone mineral density (BMD) in a large cohort of HIV-infected men, estradiol was associated with BMD, relative estrogen deficiency being involved in bone loss in men with hypogonadism, in addition to all HIV-related factors. Increased aromatization in adipose tissue does not counteract HIV-related bone loss.