Curcumin and tetrahydrocurcumin both prevent osteoarthritis symptoms and decrease the expressions of pro-inflammatory cytokines in estrogen-deficient rats
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- 作者：Sunmin Park ; La Ra Lee ; Ji Hyun Seo ; Suna Kang
- 关键词：Curcumin ; Tetrahydrocurcumin ; Bone mineral density ; Lean body mass ; Estrogen deficiency ; Monoiodoacetate
- 刊名：Genes & Nutrition
- 出版年：2016
- 出版时间：December 2016
- 年：2016
- 卷：11
- 期：1
- 全文大小：1,739 KB
- 刊物主题：Human Genetics; Nutrition; Gene Function; Biomedicine general;
- 出版者：Springer Berlin Heidelberg
- ISSN：1865-3499
文摘
Background Menopausal symptoms are associated with inflammation. Curcumin is a well-known anti-inflammatory bioactive compound from turmeric whereas tetrahydrocurcumin (THC) is a major metabolite of curcumin that may have different efficacies. However, they have not been studied for anti-menopausal symptoms and anti-osteoarthritis effects. We compared the efficacies of curcumin and THC for preventing postmenopausal and osteoarthritis symptoms in ovariectomized (OVX) obese rats with monoiodoacetate (MIA) injections into the right knee to generate a similar pathology as osteoarthritis.