Photoreceptor protection via blockade of BET epigenetic readers in a murine model of inherited retinal degeneration
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- 作者：Lei Zhao ; Jun Li ; Yingmei Fu ; Mengxue Zhang ; Bowen Wang…
- 关键词：Bromodomain and extraterminal domain (BET) proteins ; Epigenetic readers ; Retinal degeneration ; Microglial activation ; JQ1 ; rd10 mice
- 刊名：Journal of Neuroinflammation
- 出版年：2017
- 出版时间：December 2017
- 年：2017
- 卷：14
- 期：1
- 全文大小：7057KB
- 刊物主题：Neurosciences; Neurology; Neurobiology; Immunology;
- 出版者：BioMed Central
- ISSN：1742-2094
- 卷排序：14
文摘
BackgroundThe bromodomain and extraterminal domain (BET) family proteins (BET2, BET3, and BET4) “read” (bind) histone acetylation marks via two distinct bromodomains (Brom1 and Brom2) facilitating transcriptional activation. These epigenetic “readers” play crucial roles in pathogenic processes such as inflammation. The role of BETs in influencing the degenerative process in the retina is however unknown.