Efficient whole-cell biocatalyst for Neu5Ac production by manipulating synthetic, degradation and transmembrane pathways

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• 作者：Deqiang Zhu ; Xiaobei Zhan ; Jianrong Wu ; Minjie Gao…
• 关键词：Coexpressing vector ; GlcNAc ; specific PTS ; Neu5Ac ; NeuNAc synthase ; Phosphoenolpyruvate ; Whole ; cell biocatalyst
• 刊名：Biotechnology Letters
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：39
• 期：1
• 页码：55-63
• 全文大小：
• 刊物类别：Biomedical and Life Sciences
• 刊物主题：Microbiology; Biotechnology; Applied Microbiology; Biochemistry, general;
• 出版者：Springer Netherlands
• ISSN：1573-6776
• 卷排序：39

文摘

ObjectiveTo develop a strategy for producing N-acetyl-d-neuraminic acid (Neu5Ac), which is often synthesized from exogenous N-acetylglucosamine (GlcNAc) and pyruvate, but without using pyruvate.