Cupressus sempervirens extract inhibited human basal cell carcinoma tumorigenesis, local invasion, and angiogenic property

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• 作者：Mehdi Amirnia ; Fatemeh Mokhtari ; Aysa Rezabakhsh…
• 关键词：Human basal cell carcinoma ; Cupressus sempervirens ; Oncostatic and anti ; angiogenic effects ; Metastatic properties
• 刊名：Comparative Clinical Pathology
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：26
• 期：1
• 页码：203-211
• 全文大小：
• 刊物类别：Medicine
• 刊物主题：Pathology; Hematology; Oncology;
• 出版者：Springer London
• ISSN：1618-565X
• 卷排序：26

文摘

Basal cell carcinoma, a noninvasive and rarely metastatic tumor, correlates with clinical and histological involvement of basal epithelial cells. It occurs due to dysregulation of hedgehog-patched1 signaling pathway. The current study was conducted to evaluate the in vitro cytotoxic effects of Cupressus sempervirens methanolic extract against primary basal cell carcinoma cells, over a period of 48 h. We measured protein level of Annexin-V and the leakage rate of lactate dehydrogenase in cells being exposed to 420 μM extract. In addition to transcript levels of PTCH-1, a receptor of  of hedgehog signaling pathway, angiogenic activity of tumor cells were determined in terms of the amount of vascular endothelial growth factor and angiopoietin-2, and metastatic levels of matrix metalloproteinase 2 and 9.