Neutrophil Gelatinase Associated Lipocalin (NGAL) as a Biomarker. Does It Apply in Abdominal Aortic Aneurysms? A Review of Literature

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• 作者：Georgios Karaolanis ; Demetrios Moris ; Viktoria-Varvara Palla…
• 关键词：Neutrophil gelatinase associated lipocalin (NGAL) ; Abdominal aortic aneurysm (AAA) ; Biomarkers ; Growth
• 刊名：Indian Journal of Surgery
• 出版年：2015
• 出版时间：December 2015
• 年：2015
• 卷：77
• 期：3-supp
• 页码：1313-1317
• 全文大小：131 KB
• 参考文献：1.Steinberg I, Stein HL (1966) Arterosclerotic abdominal aortic aneurysms. Report of 200 consecutive cases diagnosed by intravenous aortography. JAMA 195:1025CrossRef PubMed
  2.McGregor JC, Pollock JG, Anton HC (1975) The value of ultrasonography in the diagnosis of abdominal aortic aneurysm. Scott Med J 20:133–137PubMed
  3.Wanhainen A, Thermudo R, Ahlström H, Lind L, Johansson L (2008) Thoracic and abdominal aortic dimension in 70-years old men and women—a population-based whole-body MRI study. J Vasc Surg 47:504–512CrossRef PubMed
  4.Sterpetti A, Schultz R, Feldhaus R, Cheng S, Peetz D (1987) Factors influencing enlargement rate of small abdominal aortic aneurysms. J Surg Res 43:211–219CrossRef PubMed
  5.Collin J, Walton J, Araujo L, Lindsell D (1988) Oxford screening programme for abdominal aortic aneurysm in men aged 65 to 74 years. Lancet 2:613–615CrossRef PubMed
  6.Sonesson B, Lanne T, Hansen F, Sandgren T (1994) Infrarenal aortic diameter in the healthy person. Eur J Vasc Surg 8:89–95CrossRef PubMed
  7.Chang CK, Chuter TA, Niemann CU, Shlipak MG, Cohen MJ, Reilly LM et al (2009) Systemic inflammation, coagulopathy, and acute renal insufficiency following endovascular thoracoabdominal aortic aneurysm repair. J Vasc Surg 49(5):1140–1146CrossRef PubMed PubMedCentral
  8.Sakalihasan N, Limet R, Defawe OD (2005) Abdominal aortic aneurysm. Lancet 365(9470):1577–1589CrossRef PubMed
  9.Michel JB, Thaunat O, Houard X, Meilhac O, Caligiuri G, Nicoletti A (2007) Topological determinants and consequences of adventitial responses to arterial wall injury. Arterioscler Thromb Vasc Biol 27(6):1259–1268CrossRef PubMed
  10.Devarajan P (2007) Emerging biomarkers of acute kidney injury. Contrib Nephrol 156:203–212CrossRef PubMed
  11.Devarajan P (2010) Neutrophil gelatinase-associated lipocalin: a promising biomarker for human acute kidney injury. Biomark Med 4(2):265–280CrossRef PubMed PubMedCentral
  12.Akerstrom B, Flower DR, Salier JP (2000) Lipocalins: unity in diversity. Biochim Biophys Acta 1482:1–8CrossRef PubMed
  13.Goetz DH, Holmes MA, Borregaard N et al (2002) The neutrophillipocalin NGAL is a bacteriostatic agent that interferes with siderophore-mediated iron acquisition. Mol Cell 10:1033–1043CrossRef PubMed
  14.Kol A, Sukhova GK, Lichtman AH et al (1998) Chlamydial-heat shock protein 60 localizes in human atheroma and regulates macrophage tumor necrosis factor-alpha and matrix metalloproteinase expression. Circulation 98:300–307CrossRef PubMed
  15.Kjeldsen L, Cowland JB, Borregaard N (2000) Human neutrophil gelatinase-associated lipocalin and homologous proteins in rat and mouse. Biochim Biophys Acta 1482(1–2):272–283CrossRef PubMed
  16.Devarajan P (2010) The promise of biomarkers for personalized renal cancer care. Kidney Int 77(9):755–757CrossRef PubMed
  17.Ramos-Mozo P, Madrigal-Matute J, Vega de Ceniga M, Blanco-Colio LM, Meilhac O, Feldman L et al (2012) Increased plasma levels of NGAL, a marker of neutrophil activation, in patients with abdominal aortic aneurysm. Atherosclerosis 220(2):552–556CrossRef PubMed
  18.Elneihoum AM, Falke P, Hedblad B, Lindgärde F, Ohlsson K (1997) Leukocyte activation in atherosclerosis: correlation with risk factors. Atherosclerosis 131(1):79–84CrossRef PubMed
  19.Yndestad A, Landrø L, Ueland T, Dahl CP, Flo TH, Vinge LE et al (2009) Increased systemic and myocardial expression of neutrophil gelatinase-associated lipocalin in clinical and experimental heart failure. Eur Heart J 30(10):1229–1236CrossRef PubMed
  20.Giaginis C, Zira A, Katsargyris A, Klonaris C, Theocharis S (2010) Clinical implication of plasma neutrophil gelatinase-associated lipocalin (NGAL) concentrations in patients with advanced carotid atherosclerosis. Clin Chem Lab Med 48(7):1035–1041CrossRef PubMed
  21.Elneihoum AM, Falke P, Axelsson L, Lundberg E, Lindgärde F, Ohlsson K (1996) Leukocyte activation detected by increased plasma levels of inflammatory mediators in patients with ischemic cerebrovascular diseases. Stroke 27(10):1734–1738CrossRef PubMed
  22.Anwaar I, Gottsäter A, Ohlsson K, Mattiasson I, Lindgärde F (1998) Increasing levels of leukocyte-derived inflammatory mediators in plasma and cAMP in platelets during follow-up after acute cerebral ischemia. Cerebrovasc Dis 8(6):310–317CrossRef PubMed
  23.Houard X, Ollivier V, Louedec L, Michel JB, Bäck M (2009) Differential inflammatory activity across human abdominal aortic aneurysms reveals neutrophil-derived leukotriene B4 as a major chemotactic factor released from the intraluminal thrombus. FASEB J 23(5):1376–1383CrossRef PubMed
  24.Eliason JL, Hannawa KK, Ailawadi G, Sinha I, Ford JW, Deogracias MP et al (2005) Neutrophil depletion inhibits experimental abdominal aortic aneurysm formation. Circulation 112(2):232–240CrossRef PubMed
  25.Folkesson M, Kazi M, Zhu C, Silveira A, Hemdahl AL, Hamsten A et al (2007) Presence of NGAL/MMP-9 complexes in human abdominal aortic aneurysms. Thromb Haemost 98(2):427–433PubMed
  26.Yoshimura K, Aoki H, Ikeda Y, Furutani A, Hamano K, Matsuzaki M (2006) Regression of abdominal aortic aneurysm by inhibition of c-Jun N-terminal kinase in mice. Ann N Y Acad Sci 1085:74–81CrossRef PubMed
  27.Flo TH, Smith KD, Sato S, Rodriguez DJ, Holmes MA, Strong RK et al (2004) Lipocalin 2 mediates an innate immune response to bacterial infection by sequestrating iron. Nature 432(7019):917–921CrossRef PubMed
  28.Delbosc S, Alsac JM, Journe C, Louedec L, Castier Y, Bonnaure-Mallet M et al (2011) Porphyromonas gingivalis participates in pathogenesis of human abdominal aortic aneurysm by neutrophil activation. Proof of concept in rats. PLoS One 6(4):e18679CrossRef PubMed PubMedCentral
  29.Berger T, Togawa A, Duncan GS et al (2006) Lipocalin 2-deficient mice exhibit increased sensitivity to Escherichia coli infection but not to ischemia-reperfusion injury. Proc Natl Acad Sci U S A 103:1834–1839CrossRef PubMed PubMedCentral
  30.Juvonen T, Biancari F, Juvonen J (2002) Chlamydia pneumonia and aortic aneurysms. Scand Cardiovasc J 36:327–328CrossRef PubMed
  31.Swedenborg J, Eriksson P (2006) The intraluminal thrombus as a source of proteolytic activity. Ann N Y Acad Sci 1085:133–138CrossRef PubMed
  32.Houard X, Touat Z, Ollivier V, Louedec L, Philippe M, Sebbag U et al (2009) Mediators of neutrophil recruitment in human abdominal aortic aneurysms. Cardiovasc Res 82(3):532–541CrossRef PubMed PubMedCentral
  33.Grigoryev DN, Liu M, Hassoun HT et al (2008) The local and systemic inflammatory transcriptome after acute kidney injury. J Am Soc Nephrol 19:547–558CrossRef PubMed PubMedCentral
  34.Kokot M, Biolik G, Ziaja D et al (2012) Acute kidney injury after abdominal aortic aneurysm surgery: detailed assessment of early effects using novel markers. Pol Arch Med Wewn 122(7–8):353–360PubMed
  35.Lacquaniti A, Giardina M, Lucisano S, Messina R, Buemi A, Risitano CD et al (2014) Neutrophil gelatinase-associated lipocalin (NGAL) and endothelial progenitor cells (EPCS) evaluation in aortic aneurysm repair. Curr Vasc Pharmacol 11(6):1001–1010CrossRef
  36.Speelman L, Schurink GW, Bosboom EM, Buth J, Breeuwer M, van de Vosse FN, Jacobs MH (2010) The mechanical role of thrombus on the growth rate of an abdominal aortic aneurysm. J Vasc Surg 51(1):19–26CrossRef PubMed
  37.Speelman L, Hellenthal FA, Pulinx B, Bosboom EM, Breeuwer M, van Sambeek MR et al (2010) The influence of wall stress on AAA growth and biomarkers. Eur J Vasc Endovasc Surg 39(4):410–416CrossRef PubMed
  
• 作者单位：Georgios Karaolanis (1)
  Demetrios Moris (2)
  Viktoria-Varvara Palla (1)
  Euridiki Karanikola (1)
  Chris Bakoyiannis (2)
  Sotirios Georgopoulos (2)
  
  1. 2nd Department of Surgery, Vascular Surgery Unit, School of Medicine, Laikon General Hospital, Athens, Greece
  2. 1st Department of Surgery, Vascular Surgery Unit, School of Medicine, Laikon General Hospital, Athens, Greece
  
• 刊物主题：Surgery; Pediatric Surgery; Neurosurgery; Plastic Surgery; Cardiac Surgery; Thoracic Surgery;
• 出版者：Springer India
• ISSN：0973-9793

文摘

Neutrophil gelatinase associated lipocalin (NGAL) as a protein derived from neutrophils has recently been the field of investigation in a wide range of diseases (renal disease, coronary artery disease, etc). The MEDLINE/PubMed database was searched for publications with the medical subject heading “NGAL” and keywords “Abdominal aortic aneurysm (AAA),” “biomarker,” and “growth”. We restricted our search to date. In this review, we included 38 articles and abstracts that were accessible and available in English. An effort to further explain the role of NGAL within AAA has been made. NGAL seems to be a hopeful marker for the pathogenesis and the progression of abdominal aortic aneurysms (AAAs), which has significant morbidity and mortality rates.