Successful Treatment of Paecilomyces variotii Peritonitis in a Liver Transplant Patient

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• 作者：Meltem Polat ; Soner Sertan Kara ; An?l Tap?s?z ; Zeliha Demirta?…
• 关键词：Amphotericin B ; Liver transplant ; Paecilomyces variotii peritonitis ; Voriconazole
• 刊名：Mycopathologia
• 出版年：2015
• 出版时间：April 2015
• 年：2015
• 卷：179
• 期：3-4
• 页码：317-320
• 全文大小：166 KB
• 参考文献：1. Pastor, FJ, Guarro, J (2006) Clinical manifestations, treatment and outcome of Paecilomyces lilacinus infections. Clin Microbiol Infect. 12: pp. 948-960 CrossRef
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• 刊物类别：Biomedical and Life Sciences
• 刊物主题：Life Sciences
  Microbiology
  Medical Microbiology
  Plant Sciences
  Microbial Ecology
  
• 出版者：Springer Netherlands
• ISSN：1573-0832

文摘

Paecilomyces variotii has previously been reported as a causative pathogen for peritonitis in patients on continuous ambulatory peritoneal dialysis and shown to be usually sensitive to amphotericin B and resistant to voriconazole. We report the first case, to our knowledge, of P. variotii peritonitis in a liver transplant patient, which was unresponsive to initial liposomal amphotericin B (L-AmB) treatment and resolved dramatically after the addition of voriconazole. The present case provides evidence for the clinical and microbiological effectiveness of voriconazole combined with L-AmB in treating P. variotii peritonitis refractory to initial L-AmB treatment.