Activation of Neutrophils via IP3 Pathway Following Exposure to Demodex-Associated Bacterial Proteins
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- 作者：Fred McMahon ; Nessa Banville ; David A. Bergin ; Christian Smedman…
- 关键词：Bacillus ; Demodex ; inflammation ; neutrophils ; rosacea
- 刊名：Inflammation
- 出版年：2016
- 出版时间：February 2016
- 年：2016
- 卷：39
- 期：1
- 页码：425-433
- 全文大小：892 KB
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Nessa Banville (2)
David A. Bergin (2)
Christian Smedman (3)
Staffan Paulie (3)
Emer Reeves (2)
Kevin Kavanagh (1)
1. Department of Biology, Maynooth University, Co. Kildare, Ireland
2. Respiratory Research Division, Department of Medicine, Royal College of Surgeons in Ireland, Beaumont Hospital, Dublin 9, Ireland
3. Mabtech AB, Nacka Strand, Sweden - 刊物类别：Medicine
- 刊物主题：Medicine & Public Health
Rheumatology
Internal Medicine
Pharmacology and Toxicology
Pathology - 出版者：Springer Netherlands
- ISSN：1573-2576
文摘
Rosacea is a chronic inflammatory condition that predominantly affects the skin of the face. Sera from rosacea patients display elevated reactivity to proteins from a bacterium (Bacillus oleronius) originally isolated from a Demodex mite from a rosacea patient suggesting a possible role for bacteria in the induction and persistence of this condition. This work investigated the ability of B. oleronius proteins to activate neutrophils and demonstrated activation via the IP3 pathway. Activated neutrophils displayed increased levels of IP1 production, F-actin formation, chemotaxis, and production of the pro-inflammatory cytokines IL-1β and IL-6 following stimulation by pure and crude B. oleronius protein preparations (2 μg/ml), respectively. In addition, neutrophils exposed to pure and crude B. oleronius proteins (2 μg/ml) demonstrated increased release of internally stored calcium (Ca2+), a hallmark of the IP3 pathway of neutrophil activation. Neutrophils play a significant role in the inflammation associated with rosacea, and this work demonstrates how B. oleronius proteins can induce neutrophil recruitment and activation. KEY WORDS Bacillus Demodex inflammation neutrophils rosacea