CD4+ and CD8+ T cells in the peripheral blood of dogs affected with generalised demodicosis

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• 作者：B. Sudhakara Reddy ; S. Sivajothi
• 关键词：Demodex mites ; Dogs ; CD4+ ; CD8+ ; Immunity
• 刊名：Comparative Clinical Pathology
• 出版年：2016
• 出版时间：March 2016
• 年：2016
• 卷：25
• 期：2
• 页码：295-297
• 全文大小：443 KB
• 参考文献：Blount DG, Pritchard DI, Heaton PR (2005) Age related alterations to immune parameters in Labrador retriever dogs. Vet Immunol Immunopathol 108:399–407CrossRef PubMed
  Faldyna ML, Leva L, Knotigova P, Toman M (2001) Lymphocyte subsets in peripheral blood of dogs a flow cytometric study. Vet Immunol Immunopathol 82:23–37CrossRef PubMed
  Fukata T, Fuoki S, Yoshikawa H, Kambayashi Y, Kito K, Kitagawa H (2005) Significance of the CD4/CD8 lymphocytes ratio in dogs suffering from demodicosis. J Jpn Vet Med Assoc 58:113–116CrossRef
  Reddy BS, Kumari KN (2010) Demodicosis and its successful management in dogs. Ind J Field Veterinarians 6(2):48–50
  Reddy BS, Sivajothi S (2014) Notoedric mange associated with Malassezia in cats. Int J Vet Health Sci Res 02(01):18–20
  Reddy BS, Kumari KN, Sivajothi S, Venkatasivakumar R (2014) Dermatitis due to mixed Demodex and Sarcoptes mites in dogs. Hindawi Publishing Corporation Case Reports in Veterinary Medicine Volume 2014, Article ID 768242, 4 pages doi:10.​1155/​2014/​768242
  Reddy BS, Kumari KN, Sivajothi S (2015) Haemato–biochemical findings and thyroxin levels in canine demodicosis. Comp Clin Pathol 24(2):287--290. doi:10.​1007/​s00580-014-1893-y CrossRef
  Singh SK, Dimri U, Sharma MC, Sharma B, Saxena M (2010) Determination of CD4+ and CD8+ T cells in the peripheral blood of dogs with demodicosis. Parasitology 137(13):1921–4CrossRef PubMed
  Sivajothi S, Reddy BS (2015) Cat affected with sarcoptic mange in YSR District of Andhra Pradesh, India. Comp Clin Pathol 24(5):1031--1032. doi:10.​1007/​s00580-014-2023-6 CrossRef
  
• 作者单位：B. Sudhakara Reddy (1)
  S. Sivajothi (2)
  
  1. Teaching Veterinary Clinical Complex (Veterinary Medicine), College of Veterinary Science, Sri Venkateswara Veterinary University, Proddatur, 516360, Andhra Pradesh, India
  2. Department of Veterinary Parasitology, College of Veterinary Science, Sri Venkateswara Veterinary University, Proddatur, 516360, Andhra Pradesh, India
  
• 刊物类别：Medicine
• 刊物主题：Medicine & Public Health
  Pathology
  Hematology
  Oncology
  
• 出版者：Springer London
• ISSN：1618-565X

文摘

Canine generalised demodicosis is recognised as a severe skin disease of dogs, and studies on CD4+ and CD8+ T cells in this disease condition have been limited. The aim of the present study was to record the CD4+ and CD8+ T cells in the peripheral blood of dogs affected with generalised demodicosis. Whole blood was collected from dogs with generalised demodicosis for estimation of CD4+ and CD8+ T cells by flow cytometry. The demodicosis-affected dogs had lower number of CD4+ T cells, increased CD8+ T cells, and reduced CD4+/CD8+ ratio compared to healthy controls. Present abnormalities in the study are related to the immunological response of the dogs to the mites in a disease process.