Antiviral effect of compounds derived from the seeds of m class="a-plus-plus">Mammea americana m> and m class="a-plus-plus">Tabernaemontana cymosa m> on Dengue and Chikungunya virus infections
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- 作者：Cecilia Gómez-Calderón ; Carol Mesa-Castro…
- 关键词：Dengue Virus ; Chikungunya Virus ; Antiviral ; Mammea americana ; Tabernaemontana cymosa
- 刊名：BMC Complementary and Alternative Medicine
- 出版年：2017
- 出版时间：December 2017
- 年：2017
- 卷：17
- 期：1
- 全文大小：873KB
- 刊物主题：Complementary & Alternative Medicine; Internal Medicine; Chiropractic Medicine;
- 出版者：BioMed Central
- ISSN：1472-6882
- 卷排序：17
文摘
BackgroundThe transmission of Dengue virus (DENV) and Chikungunya virus (CHIKV) has increased worldwide, due in part to the lack of a specific antiviral treatment. For this reason, the search for compounds with antiviral potential, either as licensed drugs or in natural products, is a research priority. The objective of this study was to identify some of the compounds that are present in Mammea americana (M. americana) and Tabernaemontana cymosa (T. cymosa) plants and, subsequently, to evaluate their cytotoxicity in VERO cells and their potential antiviral effects on DENV and CHIKV infections in those same cells.