Comparison of two quantitative proton density mapping methods in multiple sclerosis

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• 作者：René-Maxime Gracien ; Sarah C. Reitz…
• 关键词：Quantitative MRI ; Proton density ; Fatouros equation ; Relapsing ; remitting multiple sclerosis
• 刊名：Magnetic Resonance Materials in Physics, Biology and Medicine
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：30
• 期：1
• 页码：75-83
• 全文大小：
• 刊物主题：Imaging / Radiology; Computer Appl. in Life Sciences; Solid State Physics; Biomedical Engineering; Health Informatics;
• 出版者：Springer Berlin Heidelberg
• ISSN：1352-8661
• 卷排序：30

文摘

ObjectiveProton density (PD) mapping requires correction for the receive profile (RP), which is frequently performed via bias-field correction. An alternative RP-mapping method utilizes a comparison of uncorrected PD-maps and a value ρ(T1) directly derived from T1-maps via the Fatouros equation. This may be problematic in multiple sclerosis (MS), if respective parameters are only valid for healthy brain tissue. We aimed to investigate whether the alternative method yields correct PD values in MS patients.