Bone metabolism in adolescent girls with eating disorders and weight loss: independent effects of weight change, insulin-like growth factor-1 and oestradiol

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• 作者：Ingemar Swenne (1)
  Mats Stridsberg (2)
  
  1. Department of Women鈥檚 and Children鈥檚 Health ; Uppsala University Children鈥檚 Hospital ; 751 85 ; Uppsala ; Sweden
  2. Department of Medical Sciences ; Clinical Chemistry ; Uppsala University ; Uppsala ; Sweden
  
• 关键词：Eating disorder ; Adolescent ; Osteocalcin ; C ; terminal telopeptide of collagen ; Oestradiol ; Insulin ; like growth factor ; 1
• 刊名：Eating and Weight Disorders - Studies on Anorexia, Bulimia and Obesity
• 出版年：2015
• 出版时间：March 2015
• 年：2015
• 卷：20
• 期：1
• 页码：33-41
• 全文大小：273 KB
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• 刊物主题：Psychiatry;
• 出版者：Springer International Publishing
• ISSN：1590-1262

文摘

Adolescents with eating disorders (ED) are at risk of developing osteoporosis if weight is not recovered. Previous investigations do not separate the effects of weight change per se from those of concomitant hormonal changes. In this investigation serum osteocalcin (OC), C-terminal telopeptide of collagen (CTX), insulin-like growth factor-1 (IGF-1) and oestradiol were measured at assessment of 498 girls with ED and during weight gain of 59 girls. At assessment, OC concentrations were associated independently with weight (change), IGF-1 and oestradiol. Low weight, a high rate of weight loss and the hormone concentrations were associated with low OC. Low weight and high rate of weight loss were associated with high CTX concentrations but there were no associations independent of weight (change) with the hormones. During weight recovery, OC and CTX were independently and positively associated with weight, weight gain, IGF-1 and oestradiol. Bone metabolism markers are related to weight change independently of IGF-1 and oestradiol during both weight loss and weight gain. During weight gain, when pubertal development and growth are resumed there is an additional independent positive association between the markers and IGF-1 and oestradiol. These relationships are strongest in premenarcheal girls.