Developmental Origin of the Posterior Pigmented Epithelium of Iris

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• 作者：Xiaobing Wang (1)
  Kai Xiong (1)
  Lei Lu (3)
  Dandan Gu (1)
  Songtao Wang (1)
  Jing Chen (1)
  Honglei Xiao (1)
  Guomin Zhou (1) (2)
  
  1. Department of Anatomy ; Histology and Embryology ; School of Basic Medical Sciences ; Fudan University ; Shanghai ; 200032 ; China
  3. Department of Neurology ; Medical Center ; Columbia University ; New York ; NY ; 10032 ; USA
  2. Key Laboratory of Medical Imaging Computing and Computer Assisted Intervention of Shanghai ; Fudan University ; Shanghai ; 200032 ; China
  
• 关键词：Iris ; Development ; RPE ; Retina ; Embryo
• 刊名：Cell Biochemistry and Biophysics
• 出版年：2015
• 出版时间：March 2015
• 年：2015
• 卷：71
• 期：2
• 页码：1067-1076
• 全文大小：4,993 KB
• 参考文献：1. Thumann, G. (2001). Development and cellular functions of the iris pigment epithelium. / Survey of Ophthalmology, / 45, 345鈥?54. CrossRef
  2. Davis-Silberman, N., & Ashery-Padan, R. (2008). Iris development in vertebrates; genetic and molecular considerations. / Brain Research, / 1192, 17鈥?8. CrossRef
  3. Moore, K. L. (1982). / The developing human-clinical oriented embryology. Philadelphia: W.B. Saunders Company.
  4. Larsen, W. J. (2002). / Human embryology: health science Asia. Amsterdam: Elsevier Science.
  5. Sweeney, L. J. (2003). / Basic concepts in embryology. Beijing: Peking University Medical Press.
  6. Sadler, T. W. (2004). / Langman鈥檚 medical embryology. Baltimore: Lippincott Williams & Wilkins.
  7. Dudek, R. W. (2011). / Embryology. Baltimore: Lippincott Williams & Wilkins.
  8. Bovolenta, P., Mallamaci, A., Briata, P., Corte, G., & Boncinelli, E. (1997). Implication of OTX2 in pigment epithelium determination and neural retina differentiation. / Journal of Neuroscience, / 17, 4243鈥?252.
  9. Taranova, O. V., Magness, S. T., Fagan, B. M., Wu, Y. Q., Surzenko, N., Hutton, S. R., et al. (2006). SOX2 is a dose-dependent regulator of retinal neural progenitor competence. / Genes & Development, / 20, 1187鈥?202. CrossRef
  10. Beby, F., Housset, M., Fossat, N., Le Greneur, C., Flamant, F., Godement, P., et al. (2010). Otx2 gene deletion in adult mouse retina induces rapid RPE dystrophy and slow photoreceptor degeneration. / PLoS ONE, / 5, e11673. CrossRef
  11. Omori, Y., Katoh, K., Sato, S., Muranishi, Y., Chaya, T., Onishi, A., et al. (2011). Analysis of transcriptional regulatory pathways of photoreceptor genes by expression profiling of the Otx2-deficient retina. / PLoS ONE, / 6, e19685. CrossRef
  12. Matsushima, D., Heavner, W., & Pevny, L. H. (2011). Combinatorial regulation of optic cup progenitor cell fate by SOX2 and PAX6. / Development, / 138, 443鈥?54. CrossRef
  13. Ma, W., Yan, R., Li, X., & Wang, S. (2009). Reprogramming retinal pigment epithelium to differentiate toward retinal neurons with Sox2. / Stem Cells, / 27, 1376鈥?387. CrossRef
  14. Tsukiji, N., Nishihara, D., Yajima, I., Takeda, K., Shibahara, S., & Yamamoto, H. (2009). Mitf functions as an in ovo regulator for cell differentiation and proliferation during development of the chick RPE. / Development Biology, / 326, 335鈥?46. CrossRef
  15. Kim, J. S., Min, J., Recknagel, A. K., Riccio, M., & Butcher, J. T. (2011). Quantitative three-dimensional analysis of embryonic chick morphogenesis via microcomputed tomography. / Anat Rec (Hoboken), / 294, 1鈥?0. CrossRef
  16. Roy, D., Steyer, G. J., Gargesha, M., Stone, M. E., & Wilson, D. L. (2009). 3D cryo-imaging: a very high-resolution view of the whole mouse. / Anat Rec (Hoboken), / 292, 342鈥?51. CrossRef
  17. Takeda, K., Yokoyama, S., Yasumoto, K., Saito, H., Udono, T., Takahashi, K., et al. (2003). OTX2 regulates expression of DOPAchrome tautomerase in human retinal pigment epithelium. / Biochemical and Biophysical Research Communications, / 300, 908鈥?14. CrossRef
  18. Martinez-Morales, J. R., Dolez, V., Rodrigo, I., Zaccarini, R., Leconte, L., Bovolenta, P., et al. (2003). OTX2 activates the molecular network underlying retina pigment epithelium differentiation. / Journal of Biological Chemistry, / 278, 21721鈥?1731. CrossRef
  19. Sakami, S., Hisatomi, O., Sakakibara, S., Liu, J., Reh, T. A., & Tokunaga, F. (2005). Downregulation of Otx2 in the dedifferentiated RPE cells of regenerating newt retina. / Brain Research. Developmental Brain Research, / 155, 49鈥?9. CrossRef
  20. Westenskow, P., Piccolo, S., & Fuhrmann, S. (2009). Beta-catenin controls differentiation of the retinal pigment epithelium in the mouse optic cup by regulating Mitf and Otx2 expression. / Development, / 136, 2505鈥?510. CrossRef
  21. Larsen, K. B., Lutterodt, M., Rath, M. F., & Moller, M. (2009). Expression of the homeobox genes PAX6, OTX2, and OTX1 in the early human fetal retina. / International Journal of Developmental Neuroscience, / 27, 485鈥?92. CrossRef
  22. Uchikawa, M., Morishima, M., Saigou, Y., & Kondoh, H. (2010). The role of Sox2 in the regulation of eye development. / Development Biology, / 344, 484. CrossRef
  23. Westenskow, P. D., McKean, J. B., Kubo, F., Nakagawa, S., & Fuhrmann, S. (2010). Ectopic Mitf in the embryonic chick retina by co-transfection of beta-catenin and Otx2. / Investigative Ophthalmology & Visual Science, / 51, 5328鈥?335. CrossRef
  24. Masuda, T., & Esumi, N. (2010). SOX9, through Interaction with Microphthalmia-associated Transcription Factor (MITF) and OTX2, Regulates BEST1 Expression in the Retinal Pigment Epithelium. / Journal of Biological Chemistry, / 285, 26933鈥?6944. CrossRef
  25. Kosaka, M., Kodama, R., & Eguchi, G. (1998). In vitro culture system for iris-pigmented epithelial cells for molecular analysis of transdifferentiation. / Experimental Cell Research, / 245, 245鈥?51. CrossRef
  26. Albertine, K. H., & Dezawa, M. (2014). A new age of regenerative medicine: fusion of tissue engineering and stem cell research. / Anat Rec (Hoboken), / 297, 1鈥?. CrossRef
  27. Haruta, M., Kosaka, M., Kanegae, Y., Saito, I., Inoue, T., Kageyama, R., et al. (2001). Induction of photoreceptor-specific phenotypes in adult mammalian iris tissue. / Nature Neuroscience, / 4, 1163鈥?164. CrossRef
  28. Akagi, T., Mandai, M., Ooto, S., Hirami, Y., Osakada, F., Kageyama, R., et al. (2004). Otx2 homeobox gene induces photoreceptor-specific phenotypes in cells derived from adult iris and ciliary tissue. / Investigative Ophthalmology & Visual Science, / 45, 4570鈥?575. CrossRef
  29. Akagi, T., Akita, J., Haruta, M., Suzuki, T., Honda, Y., Inoue, T., et al. (2005). Iris-derived cells from adult rodents and primates adopt photoreceptor-specific phenotypes. / Investigative Ophthalmology & Visual Science, / 46, 3411鈥?419. CrossRef
  30. Thumann, G., Schraermeyer, U., Bartz-Schmidt, K. U., & Heimann, K. (1997). Descemet鈥檚 membrane as membranous support in RPE/IPE transplantation. / Current Eye Research, / 16, 1236鈥?238. CrossRef
  31. Yip, H. K. (2014). Retinal stem cells and regeneration of vision system. / Anat Rec (Hoboken), / 297, 137鈥?60. CrossRef
  
• 刊物主题：Biochemistry, general; Pharmacology/Toxicology; Biotechnology; Cell Biology; Biophysics and Biological Physics;
• 出版者：Springer US
• ISSN：1559-0283

文摘

Iris epithelium is a double-layered pigmented cuboidal epithelium. According to the current model, the neural retina and the posterior iris pigment epithelium (IPE) are derived from the inner wall of the optic cup, while the retinal pigment epithelium (RPE) and the anterior IPE are derived from the outer wall of the optic cup during development. Our current study shows evidence, contradicting this model of fetal iris development. We demonstrate that human fetal iris expression patterns of Otx2 and Mitf transcription factors are similar, while the expressions of Otx2 and Sox2 are complementary. Furthermore, IPE and RPE exhibit identical morphologic development during the early embryonic period. Our results suggest that the outer layer of the optic cup forms two layers of the iris epithelium, and the posterior IPE is the inward-curling anterior rim of the outer layer of the optic cup. These findings provide a reasonable explanation of how IPE cells can be used as an appropriate substitute for RPE cells.