Nrdp1 inhibits metastasis of colorectal cancer cells by EGFR signaling-dependent MMP7 modulation

详细信息    查看全文

• 作者：Yongsheng Jiang (1)
  Shaochuan Sun (1)
  Guoqin Liu (1)
  Bing Yan (1)
  Jun Niu (2)
  
  1. Department of General Surgery ; Jinan Central Hospital ; Shandong University ; Jinan ; 250013 ; China
  2. Department of General Surgery ; Qilu Hospital ; Shandong University ; 107 West Wenhua Road ; Jinan ; 250012 ; China
  
• 关键词：Neuregulin receptor degradation protein ; 1 (Nrdp1) ; Epidermal growth factor (EGF) ; Colorectal cancer ; MMP7
• 刊名：Tumor Biology
• 出版年：2015
• 出版时间：February 2015
• 年：2015
• 卷：36
• 期：2
• 页码：1129-1133
• 全文大小：259 KB
• 参考文献：1. East, JE, Dekker, E (2013) Colorectal cancer diagnosis in 2012: a new focus for CRC prevention鈥攎ore serration, less inflammation. Nat Rev Gastroenterol Hepatol 10: pp. 69-70 38/nrgastro.2012.245" target="_blank" title="It opens in new window">CrossRef
  2. Schaeybroeck, S, Allen, WL, Turkington, RC, Johnston, PG (2011) Implementing prognostic and predictive biomarkers in CRC clinical trials. Nat Rev Clin Oncol 8: pp. 222-32 38/nrclinonc.2011.15" target="_blank" title="It opens in new window">CrossRef
  3. Labianca, R, Beretta, GD, Mosconi, S, Pessi, MA, Milesi, L (2005) The development of clinical research in CRC. Ann Oncol 16: pp. iv37-43
  4. Pandurangan, AK (2013) Potential targets for prevention of colorectal cancer: a focus on PI3K/Akt/mTOR and Wnt pathways. Asian Pac J Cancer Prev 14: pp. 2201-5 314/APJCP.2013.14.4.2201" target="_blank" title="It opens in new window">CrossRef
  5. Qi, J, Zhu, YQ (2008) Targeting the most upstream site of Wnt signaling pathway provides a strategic advantage for therapy in colorectal cancer. Curr Drug Targets 9: pp. 548-57 38945008784911769" target="_blank" title="It opens in new window">CrossRef
  6. Bienz, M, Clevers, H (2000) Linking colorectal cancer to Wnt signaling. Cell 103: pp. 311-20 CrossRef
  7. Xu, Y, Pasche, B (2007) TGF-beta signaling alterations and susceptibility to colorectal cancer. Hum Mol Genet 16: pp. R14-20 3/hmg/ddl486" target="_blank" title="It opens in new window">CrossRef
  8. Lahm, H, Odartchenko, N (1993) Role of transforming growth factor beta in colorectal cancer. Growth Factors 9: pp. 1-9 3109/08977199308991577" target="_blank" title="It opens in new window">CrossRef
  9. Winder, T, Lenz, HJ (2010) Vascular endothelial growth factor and epidermal growth factor signaling pathways as therapeutic targets for colorectal cancer. Gastroenterology 138: pp. 2163-76 3/j.gastro.2010.02.005" target="_blank" title="It opens in new window">CrossRef
  10. Jimeno, A, Messersmith, WA, Hirsch, FR, Franklin, WA, Eckhardt, SG (2009) KRAS mutations and sensitivity to epidermal growth factor receptor inhibitors in colorectal cancer: practical application of patient selection. J Clin Oncol 27: pp. 1130-6 CrossRef
  11. Yao, YL, Shao, J, Zhang, C, Wu, JH, Zhang, QH, Wang, JJ (2013) Proliferation of colorectal cancer is promoted by two signaling transduction expression patterns: ErbB2/ErbB3/AKT and MET/ErbB3/MAPK. PLoS One 8: pp. e78086 371/journal.pone.0078086" target="_blank" title="It opens in new window">CrossRef
  12. Ye, Q, Cai, W, Zheng, Y, Evers, BM, She, QB (2014) ERK and AKT signaling cooperate to translationally regulate survivin expression for metastatic progression of colorectal cancer. Oncogene 33: pp. 1828-39 38/onc.2013.122" target="_blank" title="It opens in new window">CrossRef
  13. Fang, JY, Richardson, BC (2005) The MAPK signalling pathways and colorectal cancer. Lancet Oncol 6: pp. 322-7 CrossRef
  14. Jurchott, K, Kuban, RJ, Krech, T, Bluthgen, N, Stein, U, Walther, W (2010) Identification of Y-box binding protein 1 as a core regulator of MEK/ERK pathway-dependent gene signatures in colorectal cancer cells. PLoS Genet 6: pp. e1001231 371/journal.pgen.1001231" target="_blank" title="It opens in new window">CrossRef
  15. Li, LH, Zheng, MH, Luo, Q, Ye, Q, Feng, B, Lu, AG (2010) P21-activated protein kinase 1 induces colorectal cancer metastasis involving ERK activation and phosphorylation of FAK at Ser-910. Int J Oncol 37: pp. 951-62
  16. Ashraf, SQ, Nicholls, AM, Wilding, JL, Ntouroupi, TG, Mortensen, NJ, Bodmer, WF (2012) Direct and immune mediated antibody targeting of ERBB receptors in a colorectal cancer cell-line panel. Proc Natl Acad Sci U S A 109: pp. 21046-51 3/pnas.1218750110" target="_blank" title="It opens in new window">CrossRef
  17. Yen, L, Cao, Z, Wu, X, Ingalla, ER, Baron, C, Young, LJ (2006) Loss of Nrdp1 enhances ErbB2/ErbB3-dependent breast tumor cell growth. Cancer Res 66: pp. 11279-86 319" target="_blank" title="It opens in new window">CrossRef
  18. Lu H, Li H, Mao D, Zhu Z, Sun H. Nrdp1 inhibits growth of colorectal cancer cells by nuclear retention of p27. Tumour Biol.聽2014;35(9):8639鈥?3. doi:10.1007/s13277-014-2132-5 .
  19. Kleist, S, Chany, E, Burtin, P, King, M, Fogh, J (1975) Immunohistology of the antigenic pattern of a continuous cell line from a human colon tumor. J Natl Cancer Inst 55: pp. 555-60
  20. Song, H, Tian, Z, Qin, Y, Yao, G, Fu, S, Geng, J (2014) Astrocyte elevated gene-1 activates MMP9 to increase invasiveness of colorectal cancer. Tumour Biol 35: pp. 6679-85 3277-014-1883-3" target="_blank" title="It opens in new window">CrossRef
  21. Liu G, Jiang C, Li D, Wang R, Wang W. MiRNA-34a inhibits EGFR-signaling-dependent MMP7 activation in gastric cancer. Tumour Biol. 2014; in press.
  22. Wang F, Xiao W, Sun J, Han D, Zhu Y. MiRNA-181c inhibits EGFR-signaling-dependent MMP9 activation via suppressing Akt phosphorylation in glioblastoma. Tumour Biol, 2014; in press.
  
• 刊物主题：Cancer Research;
• 出版者：Springer Netherlands
• ISSN：1423-0380

文摘

The molecular mechanism underlying cancer invasiveness and metastasis of colorectal cancer (CRC) remains elusive. Here we reported a strong correlation of the levels of neuregulin receptor degradation protein-1 (Nrdp1) and matrix metalloproteinase-7 (MMP7) in CRC from the patients. We then used a human CRC line, Caco-2, to study the underlying molecular basis. We found that Nrdp1 inhibited the phosphorylation of ErB3, a key player in epidermal growth factor receptor (EGFR) signaling in Caco-2 cells, which is required for activation of MMP7 to promote cell invasion. Our findings thus reveal Nrdp1, EGFR signaling, and MMP7 as promising therapeutic targets for preventing the metastasis of CRC.