Downregulation of RIP140 in hepatocellular carcinoma promoted the growth and migration of the cancer cells

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• 作者：Dexiang Zhang (1)
  Yueqi Wang (1)
  Yuedi Dai (2)
  Jiwen Wang (1)
  Tao Suo (1)
  Hongtao Pan (1)
  Han Liu (1)
  Sheng Shen (1)
  Houbao Liu (1) (3)
  
  1. General Surgery Department ; Zhongshan Hospital ; General Surgery Institute ; Fudan University ; Shanghai ; 200032 ; China
  2. Department of Medical Oncology ; Cancer Hospital of Fudan University ; Minhang Branch ; Shanghai ; 200240 ; China
  3. Zhongshan Hospital ; Fudan University ; 180 Fenglin Rd ; Shanghai ; 200032 ; China
  
• 关键词：HCC ; RIP140 ; Beta ; catenin ; Cell proliferation and migration
• 刊名：Tumor Biology
• 出版年：2015
• 出版时间：March 2015
• 年：2015
• 卷：36
• 期：3
• 页码：2077-2085
• 全文大小：2,790 KB
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• 刊物主题：Cancer Research;
• 出版者：Springer Netherlands
• ISSN：1423-0380

文摘

Hepatocellular carcinoma (HCC) is one of the most common malignancies with a poor response to chemotherapy. It is very important to identify novel diagnosis biomarkers and therapeutic targets. RIP140, a regulator of estrogen receptor, recently has been found to be involved in the tumorigenesis. However, its function in the progression of HCC remains poorly understood. Here, we found that the expression of RIP140 was downregulated in the HCC tissues. Moreover, overexpression of RIP140 in HCC cells inhibited cell proliferation and migration, while downregulation of RIP140 promoted the tumorigenicity of HCC cells in vitro and in vivo. Mechanistically, RIP140 interacted with beta-catenin and negatively regulated beta-catenin/TCF signaling. Taken together, our study suggests the suppressive roles of RIP140 in the pathogenesis of HCC.