MicroRNA-206 suppresses gastric cancer cell growth and metastasis

详细信息    查看全文

• 作者：Jun Ren (1) (2)
  Hui-jie Huang (2)
  Yu Gong (1)
  Shen Yue (2)
  Li-ming Tang (1)
  Steven Y Cheng (2)
  
  1. Department of General Surgery ; Nanjing Medical University affiliated Changzhou No. 2 Hospital ; 213000 ; Changzhou ; Jiangsu ; PR. China
  2. Department of Developmental Genetics ; School of Basic Medical Sciences ; Nanjing Medical University ; 210029 ; Nanjing ; Jiangsu ; PR. China
  
• 关键词：Gastric cancer ; miR ; 206 ; Metastasis ; Tumor suppressor
• 刊名：Cell & Bioscience
• 出版年：2014
• 出版时间：December 2014
• 年：2014
• 卷：4
• 期：1
• 全文大小：1,418 KB
• 参考文献：1. Danaei, G, Vander Hoorn, S, Lopez, AD, Murray, CJ, Ezzati, M (2005) Causes of cancer in the world: comparative risk assessment of nine behavioural and environmental risk factors. Lancet 366: pp. 1784-1793 25-2" target="_blank" title="It opens in new window">CrossRef
  2. Catalano, V, Labianca, R, Beretta, GD, Gatta, G, de Braud, F, Van Cutsem, E (2009) Gastric cancer. Crit Rev Oncol Hematol 71: pp. 127-164 2009.01.004" target="_blank" title="It opens in new window">CrossRef
  3. Houghton, J, Wang, TC (2005) Helicobacter pylori and gastric cancer: a new paradigm for inflammation-associated epithelial cancers. Gastroenterology 128: pp. 1567-1578 2005.03.037" target="_blank" title="It opens in new window">CrossRef
  4. Pounder, RE, Ng, D (1995) The prevalence of Helicobacter pylori infection in different countries. Aliment Pharmacol Ther 9: pp. 33-39
  5. Coyle, WJ, Sedlack, RE, Nemec, R, Peterson, R, Duntemann, T, Murphy, M, Lawson, JM (1999) Eradication of Helicobacter pylori normalizes elevated mucosal levels of epidermal growth factor and its receptor. Am J Gastroenterol 94: pp. 2885-2889 2-0241.1999.01432.x" target="_blank" title="It opens in new window">CrossRef
  6. Chan, AO, Peng, JZ, Lam, SK, Lai, KC, Yuen, MF, Cheung, HK, Kwong, YL, Rashid, A, Chan, CK, Wong, BC (2006) Eradication of Helicobacter pylori infection reverses E-cadherin promoter hypermethylation. Gut 55: pp. 463-468 2005.077776" target="_blank" title="It opens in new window">CrossRef
  7. Ren, G, Tian, Q, An, Y, Feng, B, Lu, Y, Liang, J, Li, K, Shang, Y, Nie, Y, Wang, X, Fan, D (2007) Coronin 3 promotes gastric cancer metastasis via the up-regulation of MMP-9 and cathepsin K. Mol Cancer 11: pp. 67 CrossRef
  8. Kubben, FJ, Sier, CF, Schram, MT, Witte, AM, Veenendaal, RA, van Duijn, W, Verheijen, JH, Hanemaaijer, R, Lamers, CB, Verspaget, HW (2007) Eradication of Helicobacter pylori infection favourably affects altered gastric mucosal MMP-9 levels. Helicobacter 12: pp. 498-504 23-5378.2007.00527.x" target="_blank" title="It opens in new window">CrossRef
  9. Ushijima, T, Sasako, M (2004) Focus on gastric cancer. Cancer Cell 5: pp. 121-125 CrossRef
  10. Yokobori, T, Mimori, K, Ishii, H, Iwatsuki, M, Tanaka, F, Kamohara, Y, Ieta, K, Kita, Y, Doki, Y, Kuwano, H, Mori, M (2010) Clinical significance of stanniocalcin 2 as a prognostic marker in gastric cancer. Ann Surg Oncol 17: pp. 2601-2607 245/s10434-010-1086-0" target="_blank" title="It opens in new window">CrossRef
  11. Arigami, T, Uenosono, Y, Ishigami, S, Yanagita, S, Hagihara, T, Haraguchi, N, Matsushita, D, Hirahara, T, Okumura, H, Uchikado, Y, Nakajo, A, Hokita, S, Natsugoe, S (2013) Clinical significance of stanniocalcin 2 expression as a predictor of tumor progression in gastric cancer. Oncol Rep 30: pp. 2838-2844
  12. Okugawa, Y, Tanaka, K, Inoue, Y, Kawamura, M, Kawamoto, A, Hiro, J, Saigusa, S, Toiyama, Y, Ohi, M, Uchida, K, Mohri, Y, Kusunoki, M (2013) Brain-derived neurotrophic factor/tropomyosin-related kinase B pathway in gastric cancer. Br J Cancer 108: pp. 121-130 2012.499" target="_blank" title="It opens in new window">CrossRef
  13. Townley-Tilson, WH, Callis, TE, Wang, D (2010) MicroRNAs 1, 133, and 206: critical factors of skeletal and cardiac muscle development, function, and disease. Int J Biochem Cell Biol 42: pp. 1252-1255 2009.03.002" target="_blank" title="It opens in new window">CrossRef
  14. Nohata, N, Hanazawa, T, Enokida, H, Seki, N (2012) microRNA-1/133a and microRNA-206/133b clusters: dysregulation and functional roles in human cancers. Oncotarget 3: pp. 9-21
  15. Yoshino, H, Chiyomaru, T, Enokida, H, Kawakami, K, Tatarano, S, Nishiyama, K, Nohata, N, Seki, N, Nakagawa, M (2011) The tumour-suppressive function of miR-1 and miR-133a targeting TAGLN2 in bladder cancer. Br J Cancer 104: pp. 808-818 2011.23" target="_blank" title="It opens in new window">CrossRef
  16. Yan, D, Dong Xda, E, Chen, X, Wang, L, Lu, C, Wang, J, Qu, J, Tu, L (2009) MicroRNA-1/206 targets c-Met and inhibits rhabdomyosarcoma development. J Biol Chem 284: pp. 29596-29604 20511" target="_blank" title="It opens in new window">CrossRef
  17. O'Day, E, Lal, A (2010) MicroRNAs and their target gene networks in breast cancer. Breast Cancer Res 12: pp. 201 2484" target="_blank" title="It opens in new window">CrossRef
  18. Wang, X, Ling, C, Bai, Y, Zhao, J (2011) MicroRNA-206 is associated with invasion and metastasis of lung cancer. Anat Rec (Hoboken) 294: pp. 88-92 2/ar.21287" target="_blank" title="It opens in new window">CrossRef
  19. Lu, J, Getz, G, Miska, EA, Alvarez-Saavedra, E, Lamb, J, Peck, D, Sweet-Cordero, A, Ebert, BL, Mak, RH, Ferrando, AA, Downing, JR, Jacks, T, Horvitz, HR, Golub, TR (2005) MicroRNA expression profiles classify human cancers. Nature 435: pp. 834-838 2" target="_blank" title="It opens in new window">CrossRef
  20. Kita, Y, Mimori, K, Iwatsuki, M, Yokobori, T, Ieta, K, Tanaka, F, Ishii, H, Okumura, H, Natsugoe, S, Mori, M (2011) STC2: a predictive marker for lymph node metastasis in esophageal squamous-cell carcinoma. Ann Surg Oncol 18: pp. 261-272 245/s10434-010-1271-1" target="_blank" title="It opens in new window">CrossRef
  21. Okamura, K, Harada, T, Wang, S, Ijichi, K, Furuyama, K, Koga, T, Okamoto, T, Takayama, K, Yano, T, Nakanishi, Y (2012) Expression of TrkB and BDNF is associated with poor prognosis in non-small cell lung cancer. Lung Cancer 78: pp. 100-106 2012.07.011" target="_blank" title="It opens in new window">CrossRef
  22. Hellawell, GO, Ferguson, DJ, Brewster, SF, Macaulay, VM (2003) Chemosensitization of human prostate cancer using antisense agents targeting the type 1 insulin-like growth factor receptor. BJU Int 91: pp. 271-277 2003.04061.x" target="_blank" title="It opens in new window">CrossRef
  23. Krueckl, SL, Sikes, RA, Edlund, NM, Bell, RH, Hurtado-Coll, A, Fazli, L, Gleave, ME, Cox, ME (2004) Increased insulin-like growth factor I receptor expression and signaling are components of androgen-independent progression in a lineage-derived prostate cancer progression model. Cancer Res 64: pp. 8620-8629 2.CAN-04-2446" target="_blank" title="It opens in new window">CrossRef
  24. Fleischmann, A, Huland, H, Mirlacher, M, Wilczak, W, Simon, R, Erbersdobler, A, Sauter, G, Schlomm, T (2012) Prognostic relevance of Bcl-2 overexpression in surgically treated prostate cancer is not caused by increased copy number or translocation of the gene. Prostate 72: pp. 991-997 2/pros.21504" target="_blank" title="It opens in new window">CrossRef
  25. Kondo, N, Toyama, T, Sugiura, H, Fujii, Y, Yamashita, H (2008) miR-206 Expression is down-regulated in estrogen receptor alpha-positive human breast cancer. Cancer Res 68: pp. 5004-5008 2.CAN-08-0180" target="_blank" title="It opens in new window">CrossRef
  26. Taulli, R, Bersani, F, Foglizzo, V, Linari, A, Vigna, E, Ladanyi, M, Tuschl, T, Ponzetto, C (2009) The muscle-specific microRNA miR-206 blocks human rhabdomyosarcoma growth in xenotransplanted mice by promoting myogenic differentiation. J Clin Invest 119: pp. 2366-2378
  27. Song, G, Zhang, Y, Wang, L (2009) MicroRNA-206 targets notch3, activates apoptosis, and inhibits tumor cell migration and focus formation. J Biol Chem 284: pp. 31921-31927 2" target="_blank" title="It opens in new window">CrossRef
  28. Chen, X, Yan, Q, Li, S, Zhou, L, Yang, H, Yang, Y, Liu, X, Wan, X (2012) Expression of the tumor suppressor miR-206 is associated with cellular proliferative inhibition and impairs invasion in ERalpha-positive endometrioid adenocarcinoma. Cancer Lett 314: pp. 41-53 2011.09.014" target="_blank" title="It opens in new window">CrossRef
  29. Leong, T (2005) Chemotherapy and radiotherapy in the management of gastric cancer. Curr Opin Gastroenterol 21: pp. 673-678 28158.b7" target="_blank" title="It opens in new window">CrossRef
  30. Jiang, Y, Wang, L, Gong, W, Wei, D, Le, X, Yao, J, Ajani, J, Abbruzzese, JL, Huang, S, Xie, K (2004) A high expression level of insulin-like growth factor I receptor is associated with increased expression of transcription factor Sp1 and regional lymph node metastasis of human gastric cancer. Clin Exp Metastasis 21: pp. 755-764 2" target="_blank" title="It opens in new window">CrossRef
  31. Zhao, X, Dou, W, He, L, Liang, S, Tie, J, Liu, C, Li, T, Lu, Y, Mo, P, Shi, Y, Wu, K, Nie, Y, Fan, D (2013) MicroRNA-7 functions as an anti-metastatic microRNA in gastric cancer by targeting insulin-like growth factor-1 receptor. Oncogene 32: pp. 1363-1372 2012.156" target="_blank" title="It opens in new window">CrossRef
  32. Adachi, Y, Li, R, Yamamoto, H, Min, Y, Piao, W, Wang, Y, msumran, A, Li, H, Arimura, Y, Lee, CT, Imai, K, Carbone, DP, Shinomura, Y (2009) Insulin-like growth factor-I receptor blockade reduces the invasiveness of gastrointestinal cancers via blocking production of matrilysin. Carcinogenesis 30: pp. 1305-1313 CrossRef
  33. Terracciano, LM, Glatz, K, Mhawech, P, Vasei, M, Lehmann, FS, Vecchione, R, Tornillo, L (2003) Hepatoid adenocarcinoma with liver metastasis mimicking hepatocellular carcinoma: an immunohistochemical and molecular study of eight cases. Am J Surg Pathol 27: pp. 1302-1312 200310000-00002" target="_blank" title="It opens in new window">CrossRef
  34. Cheon, SH, Rha, SY, Jeung, HC, Im, CK, Kim, SH, Kim, HR, Ahn, JB, Roh, JK, Noh, SH, Chung, HC (2008) Survival benefit of combined curative resection of the stomach (D2 resection) and liver in gastric cancer patients with liver metastases. Ann Oncol 19: pp. 1146-1153 26" target="_blank" title="It opens in new window">CrossRef
  
• 刊物主题：Cell Biology; Microbiology;
• 出版者：BioMed Central
• ISSN：2045-3701

文摘

Gastric cancer is one of the leading causes of cancer death world-wide and carries a high rate of metastatic risk. In addition to other protein-coding oncogenes and tumor suppressor genes, microRNAs play an important role in gastric cancer tumorigenic progression. Here, we show that miR-206 is expressed at markedly low levels in a cohort of gastric tumors compared to their matching normal tissues, and in a number of gastric cancer cell lines. Down-regulation of miR-206 was particularly significant in tumors with lymphatic metastasis, local invasion, and advanced TNM staging. We find that forced expression of miR-206 suppressed the proliferation, colony-formation, and xenograft tumorigenesis of SCG-7901 cells, a line of gastric cancer cells. Forced expression of miR-206 also suppressed SCG-7901 cell migration and invasion, as well as metastasis in cell culture or tail-vein injected mouse models, respectively. The anti-metastatic effect of miR-206 is likely mediated by targeting metastasis regulatory genes STC2, HDAC4, KLF4, IGF1R, FRS2, SFRP1, BCL2, BDNF, and K-ras, which were drastically down-regulated by stable expression of exogenous miR-206 in SCG-7901 cells. Taken together, our results indicate that miR-206 is a tumor suppressor of gastric cancer acting at steps that regulate metastasis.