Solitary uterine metastasis of invasive lobular carcinoma after adjuvant endocrine therapy: a case report
详细信息 查看全文
- 作者：Masafumi Toyoshima (1)
Hideki Iwahashi (1) (3)
Takashi Shima (1)
Atsushi Hayasaka (1) (4)
Takako Kudo (1)
Hiromitsu Makino (1)
Saori Igeta (1)
Rui Matsuura (1)
Nobuko Ishigaki (1)
Kozo Akagi (1)
Junko Sakurada (2)
Hiroyoshi Suzuki (2)
Kosuke Yoshinaga (1)
1. Department of Obstetrics and Gynecology ; Sendai Medical Center ; National Hospital Organization ; 2-8-8 ; Miyagino ; Miyagino-ku ; Sendai ; Miyagi ; 983-8520 ; Japan
3. Department of Obstetrics and Gynecology ; Self-Defense Force Sendai Hospital ; Sendai ; Japan
4. Department of Obstetrics and Gynecology ; Sendai City Hospital ; Sendai ; Japan
2. Department of Pathology ; Sendai Medical Center ; National Hospital Organization ; Sendai ; Japan - 关键词：Anastrozole ; Breast cancer ; Immunohistochemistry ; Invasive lobular carcinoma ; Isolated uterine metastasis
- 刊名：Journal of Medical Case Reports
- 出版年：2015
- 出版时间：December 2015
- 年：2015
- 卷：9
- 期：1
- 全文大小：1,585 KB
- 参考文献：1. Mazur, MT, Hsueh, S, Gersell, DJ (1984) Metastases to the female genital tract. Analysis of 325 cases. Cancer. 53: pp. 1978-84 3:9<1978::AID-CNCR2820530929>3.0.CO;2-1" target="_blank" title="It opens in new window">CrossRef
2. Kumar, NB, Hart, WR (1982) Metastases to the uterine corpus from extragenital cancers. A clinicopathologic study of 63 cases. Cancer. 50: pp. 2163-9 3::AID-CNCR2820501032>3.0.CO;2-F" target="_blank" title="It opens in new window">CrossRef
3. Bonito, L, Patriarca, S, Alberico, S (1985) Breast carcinoma metastasizing to the uterus. Eur J Gynaecol Oncol. 6: pp. 211-7
4. Wasif, N, Maggard, MA, Ko, CY, Giuliano, AE (2010) Invasive lobular vs. ductal breast cancer: a stage-matched comparison of outcomes. Ann Surg Oncol 17: pp. 1862-9 34-010-0953-z" target="_blank" title="It opens in new window">CrossRef
5. Harris, M, Howell, A, Chrissohou, M, Swindell, RI, Hudson, M, Sellwood, RA (1984) A comparison of the metastatic pattern of infiltrating lobular carcinoma and infiltrating duct carcinoma of the breast. Br J Cancer. 50: pp. 23-30 38/bjc.1984.135" target="_blank" title="It opens in new window">CrossRef
6. Lamovec, J, Bracko, M (1991) Metastatic pattern of infiltrating lobular carcinoma of the breast: an autopsy study. J Surg Oncol. 48: pp. 28-33 30480106" target="_blank" title="It opens in new window">CrossRef
7. Baum, M, Budzar, AU, Cuzick, J, Forbes, J, Houghton, JH, Klijn, JGM (2002) Anastrozole alone or in combination with tamoxifen versus tamoxifen alone for adjuvant treatment of postmenopausal women with early breast cancer: first results of the ATAC randomised trial. Lancet. 359: pp. 2131-9 36(02)09088-8" target="_blank" title="It opens in new window">CrossRef
8. Ismail, SM (1999) Gynaecological effects of tamoxifen. J Clin Pathol. 52: pp. 83-8 36/jcp.52.2.83" target="_blank" title="It opens in new window">CrossRef
9. Fisher, ER, Gregorio, RM, Fisher, B, Redmond, C, Vellios, F, Sommers, SC (1975) The pathology of invasive breast cancer. A syllabus derived from findings of the National Surgical Adjuvant Breast Project (protocol no. 4). Cancer. 36: pp. 1-85 36:1<1::AID-CNCR2820360102>3.0.CO;2-4" target="_blank" title="It opens in new window">CrossRef
10. Thangavelu, A, Hewitt, MJ, Quinton, ND, Duffy, SR (2013) Neoadjuvant treatment of endometrial cancer using anastrozole: a randomised pilot study. Gynecol Oncol. 131: pp. 613-8 3.09.023" target="_blank" title="It opens in new window">CrossRef
11. Erkanli, S, Kayaselcuk, F, Kuscu, E, Bolat, F, Sakalli, H, Haberal, A (2006) Lobular carcinoma of the breast metastatic to the uterus in a patient under adjuvant anastrozole therapy. Breast. 15: pp. 558-61 CrossRef
12. Ustaalioglu, BBO, Bilici, A, Seker, M, Salman, T, Gumus, M, Barisik, NO (2009) Metastasis of lobular breast carcinoma to the uterus in a patient under anastrozole therapy. Onkologie. 32: pp. 424-6 367" target="_blank" title="It opens in new window">CrossRef
13. Arslan, D, Tural, D, Tatl谋, AM, Akar, E, Uysal, M, Erdo臒an, G (2013) Isolated uterine metastasis of invasive ductal carcinoma. Case Rep Oncol Med. 2013: pp. 793418
14. Piura, B, Yanai-Inbar, I, Rabinovich, A, Zalmanov, S, Goldstein, J (1999) Abnormal uterine bleeding as a presenting sign of metastases to the uterine corpus, cervix and vagina in a breast cancer patient on tamoxifen therapy. Eur J Obstet Gynecol Reprod Biol. 83: pp. 57-61 301-2115(98)00268-1" target="_blank" title="It opens in new window">CrossRef - 刊物主题：Medicine/Public Health, general; General Practice / Family Medicine; Public Health; Primary Care Medicine;
- 出版者：BioMed Central
- ISSN：1752-1947
文摘
Introduction Solitary uterine metastases from extragenital cancers are very rare. Breast cancer is the most frequent primary site of metastasis to the uterine corpus, with invasive lobular carcinoma more likely to spread to gynecologic organs than invasive ductal carcinoma. Case presentation A 62-year-old postmenopausal Japanese woman was diagnosed with uterine leiomyomata more than 20 years ago and had been managed conservatively until menopause. Seven years prior to her presentation, she was diagnosed with breast cancer and underwent a partial resection of her right breast for stage IIA invasive lobular carcinoma. She underwent adjuvant chemotherapy, radiotherapy, and five years of anastrozole hormonal therapy. She presented with a growing uterine mass. Her tumor marker levels were markedly increased over the course of her follow-up, but a systemic examination revealed only a solitary uterine tumor. She underwent a total abdominal hysterectomy with bilateral salpingo-oophorectomy. A histopathological examination, including detailed immunohistochemistry, confirmed metastatic invasive lobular carcinoma, infiltrating both her uterine myometrium and fibroid tissue. Conclusion We report a very rare metastatic pattern of invasive lobular carcinoma and demonstrate that gross cystic disease fluid protein-15 and mammaglobin are useful in the diagnosis of metastatic breast cancer.