Resveratrol Protects PC12 Cells from High Glucose-Induced Neurotoxicity Via PI3K/Akt/FoxO3a Pathway

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• 作者：Mi-Hua Liu (1)
  Cong Yuan (3)
  Jun He (1)
  Tian-Ping Tan (1)
  Shao-Jian Wu (1)
  Hong-Yun Fu (1)
  Jun Liu (1)
  Shan Yu (1)
  Yu-Dan Chen (1)
  Qun-Fang Le (1)
  Wei Tian (1)
  Heng-Jing Hu (4)
  Yuan Zhang (5)
  Xiao-Long Lin (2)
  
  1. Department of Clinical Laboratory ; Affiliated Nanhua Hospital ; University of South China ; No. 336 Dongfeng South Road ; Hengyang ; 421001 ; Hunan Province ; People鈥檚 Republic of China
  3. Department of Cardiology ; The First Hospital of Changsha ; Changsha City ; 410005 ; Hunan Province ; People鈥檚 Republic of China
  4. Department of Cardiology/Cardiac Catheterisation Lab ; Second Xiangya Hospital ; Central South University ; Changsha City ; 410011 ; Hunan Province ; People鈥檚 Republic of China
  5. Department of Pathology ; Mawangdui Hospital ; Changsha City ; 410016 ; Hunan Province ; People鈥檚 Republic of China
  2. Department of Pathology ; The Third People鈥檚 Hospital of Huizhou ; Huizhou City ; 516002 ; Guangdong Province ; People鈥檚 Republic of China
  
• 关键词：Resveratrol ; High glucose ; Oxidative stress ; Apoptosis ; FoxO3a
• 刊名：Cellular and Molecular Neurobiology
• 出版年：2015
• 出版时间：May 2015
• 年：2015
• 卷：35
• 期：4
• 页码：513-522
• 全文大小：1,721 KB
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• 刊物类别：Biomedical and Life Sciences
• 刊物主题：Biomedicine
  Neurosciences
  Animal Anatomy, Morphology and Histology
  
• 出版者：Springer Netherlands
• ISSN：1573-6830

文摘

Diabetes is known to be associated with neurodegenerative diseases. Resveratrol, a plant-derived polyphenolic compound found in red wine, possesses antioxidant properties. In this study, we aimed to investigate the effects of resveratrol on the phosphatidylinositol-3-kinase/protein kinase B (PI3K/Akt)/FoxO3a pathway in mediating high glucose (HG)-induced injuries in neuronal PC12 cells. PC12 cells were exposed to HG to establish a model of HG neurotoxicity. Results showed that pre-treating PC12 cells with resveratrol before exposure to HG led to increased cell viability, decreased apoptotic cells, and reactive oxygen species generation. Western blot analysis showed that HG decreased the phosphorylation of Akt and FoxO3a and led to the nuclear localization of FoxO3a. These effects were significantly alleviated by resveratrol co-treatment. Furthermore, the protective effects of resveratrol were abolished by PI3K/Akt inhibitor LY294002. All these results demonstrate that resveratrol protected the PC12 cells from HG-induced oxidative stress and apoptosis via the activation of PI3K/Akt/FoxO3a signaling pathway.