Tag-femtosecond laser-induced breakdown spectroscopy for the sensitive detection of cancer antigen 125 in blood plasma

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• 作者：Yuri Markushin (1)
  Poopalasingam Sivakumar (1)
  Denise Connolly (2)
  Noureddine Melikechi (1)
  
  1. Optical Science Center for Applied Research and Applications and Department of Physics and Engineering ; Delaware State University ; Dover ; DE ; 19901 ; USA
  2. Fox Chase Cancer Center ; Philadelphia ; PA ; 19111 ; USA
  
• 关键词：Femtosecond laser ; induced breakdown spectroscopy ; Ovarian cancer biomarker ; CA 125 ; In vitro diagnostics ; Element encoded immunoassay ; Magnetic separation
• 刊名：Analytical and Bioanalytical Chemistry
• 出版年：2015
• 出版时间：March 2015
• 年：2015
• 卷：407
• 期：7
• 页码：1849-1855
• 全文大小：668 KB
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• 刊物类别：Chemistry and Materials Science
• 刊物主题：Chemistry
  Analytical Chemistry
  Food Science
  Inorganic Chemistry
  Physical Chemistry
  Monitoring, Environmental Analysis and Environmental Ecotoxicology
  
• 出版者：Springer Berlin / Heidelberg
• ISSN：1618-2650

文摘

Successful treatment of cancers requires detecting early signs of the disease. One promising way to approach this is to develop minimally invasive tests for the sensitive and specific detection of biomarkers in blood. Irrespective of the detection approach one uses, this remains a challenging task because biomarkers are typically present in low concentrations and there are signals that interfere strongly with prevailing compounds of human fluids. In this paper, we show that elemental encoded particle assay coupled with femtosecond laser-induced breakdown spectroscopy for simultaneous multi-elemental analysis can significantly improve biomarker detectability. An estimated near single molecule per particle efficiency of this method leads to sensitive detection of ovarian cancer biomarker CA125 in human blood plasma. This work opens new ways for earlier detection of cancers and for multiplex assay developments in various analytical applications from proteomics, genomics, and neurology fields.