Neural mechanisms of negative reinforcement in children and adolescents with autism spectrum disorders
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- 作者：Cara R Damiano (1) (2)
Dillon C Cockrell (1) (3)
Kaitlyn Dunlap (4)
Eleanor K Hanna (2) (5)
Stephanie Miller (2) (6)
Joshua Bizzell (4) (7)
Megan Kovac (8)
Lauren Turner-Brown (2) (9)
John Sideris (10)
Jessica Kinard (2)
Gabriel S Dichter (1) (2) (4) (7)
1. Department of Psychology ; University of North Carolina at Chapel Hill ; CB #3270 ; Davie Hall ; 27599-3270 ; Chapel Hill ; NC ; USA
2. Carolina Institute for Developmental Disabilities ; University of North Carolina at Chapel Hill School of Medicine ; CB #7255 ; 27599-7255 ; Chapel Hill ; NC ; USA
3. Virginia Tech Carilion School of Medicine and Research Institute ; 2 Riverside Circle Suite M140 ; 24016 ; Roanoke ; VA ; USA
4. Brain Imaging and Analysis Center (BIAC) ; Duke University Medical Center ; 2424 Erwin Road Suite 501 ; 27708 ; Durham ; NC ; USA
5. Center for Cognitive Neuroscience ; Duke University ; Box # 90999 ; 27708 ; Durham ; NC ; USA
6. UNC School of Social Work ; University of North Carolina at Chapel Hill School of Education ; CB #3550 ; 27599-3550 ; Chapel Hill ; NC ; USA
7. Department of Psychiatry ; University of North Carolina at Chapel Hill School of Medicine ; CB #7160 ; 27599-7160 ; Chapel Hill ; NC ; USA
8. School Psychology Program ; University of North Carolina at Chapel Hill School of Education ; CB #3550 ; 27599-3550 ; Chapel Hill ; NC ; USA
9. TEACCH Autism Program ; CB# 7180 UNC-Chapel Hill ; 27599-7180 ; Chapel Hill ; NC ; USA
10. Frank Porter Graham Child Development Institute ; University of North Carolina at Chapel Hill ; CB #8185 ; 27599-8185 ; Chapel Hill ; NC ; USA - 关键词：Autism spectrum disorders (ASD) ; Negative reinforcement ; Reward processing ; Social motivation ; Reward loss ; Reward motivation
- 刊名：Journal of Neurodevelopmental Disorders
- 出版年：2015
- 出版时间：December 2015
- 年：2015
- 卷：7
- 期：1
- 全文大小：954 KB
- 参考文献：Diagnostic and statistical manual of mental disorders: DSM-V. American Psychiatric Association, Washington, DC
1. Dawson, G, Toth, K, Abbott, R, Osterling, J, Munson, J, Estes, A (2004) Early social attention impairments in autism: social orienting, joint attention, and attention to distress. Dev Psychol 40: pp. 271-82 49.40.2.271" target="_blank" title="It opens in new window">CrossRef
2. Chevallier, C, Kohls, G, Troiani, V, Brodkin, ES, Schultz, RT (2012) The social motivation theory of autism. Trends Cogn Sci 16: pp. 231-9 CrossRef
3. Chevallier, C, Gr猫zes, J, Molesworth, C, Berthoz, S, Happ茅, F (2011) Brief report: selective social anhedonia in high functioning autism. J Autism Dev Disord 42: pp. 1504-9 4-0" target="_blank" title="It opens in new window">CrossRef
4. Soderstrom, H, Rastam, M, Gillberg, C (2002) Temperament and character in adults with Asperger syndrome. Autism 6: pp. 287-7 CrossRef
5. Chawarska, K, Volkmar, F, Klin, A (2010) Limited attentional bias for faces in toddlers with autism spectrum disorders. Arch Gen Psychiatry 67: pp. 178-85 psychiatry.2009.194" target="_blank" title="It opens in new window">CrossRef
6. Dichter, GS, Damiano, CR, Allen, JA (2012) Reward circuitry dysfunction in psychiatric and neurodevelopmental disorders and genetic syndromes: animal models and clinical findings. J Neurodev Dis 4: pp. 1-43 4-1" target="_blank" title="It opens in new window">CrossRef
7. Dichter, GS, Richey, JA, Rittenberg, AM, Sabatino, A, Bodfish, JW (2012) Reward circuitry function in autism during face anticipation and outcomes. J Autism Dev Disord 42: pp. 147-60 CrossRef
8. Scott-Van Zeeland, AA, Dapretto, M, Ghahremani, DG, Poldrack, RA, Bookheimer, SY (2010) Reward processing in autism. Autism Res 3: pp. 53-67
9. Delmonte, S, Balsters, JH, McGrath, J, Fitzgerald, J, Brennan, S, Fagan, AJ (2012) Social and monetary reward processing in autism spectrum disorders. Mol Autism 3: pp. 7 40-2392-3-7" target="_blank" title="It opens in new window">CrossRef
10. Dichter, GS, Felder, JN, Green, SR, Rittenberg, AM, Sasson, NJ, Bodfish, JW (2012) Reward circuitry function in autism spectrum disorders. Soc Cogn Affect Neurosci 7: pp. 160-72 CrossRef
11. Everitt, BJ, Robbins, TW (2005) Neural systems of reinforcement for drug addiction: from actions to habits to compulsion. Nat Neurosci 8: pp. 1481-9 CrossRef
12. South, M, Dana, J, White, SE, Crowley, MJ (2011) Failure is not an option: risk-taking is moderated by anxiety and also by cognitive ability in children and adolescents diagnosed with an autism spectrum disorder. J Autism Dev Disord 41: pp. 55-65 CrossRef
13. Larson, MJ, South, M, Krauskopf, E, Clawson, A, Crowley, MJ (2011) Feedback and reward processing in high-functioning autism. Psychiatry Res 187: pp. 198-203 CrossRef
14. Gray, JA, Kumari, V, Lawrence, N, Young, AM (1999) Functions of the dopaminergic innervation of the nucleus accumbens. Psychobiology 27: pp. 225-35
15. Young, PT (1959) The role of affective processes in learning and motivation. Psychol Rev 66: pp. 104-25 45997" target="_blank" title="It opens in new window">CrossRef
16. Horvitz, J (2000) Mesolimbocortical and nigrostriatal dopamine responses to salient non-reward events. Neuroscience 96: pp. 651-6 4522(00)00019-1" target="_blank" title="It opens in new window">CrossRef
17. Salamone, JD (1994) The involvement of nucleus accumbens dopamine in appetitive and aversive motivation. Behav Brain Res 61: pp. 117-33 4328(94)90153-8" target="_blank" title="It opens in new window">CrossRef
18. Delgado, MR, Nystrom, LE, Fissell, C, Noll, D, Fiez, JA (2000) Tracking the hemodynamic responses to reward and punishment in the striatum. J Neurophysiol 84: pp. 3072-7
19. Tom, SM, Fox, CR, Trepel, C, Poldrack, RA (2007) The neural basis of loss aversion in decision-making under risk. Science 315: pp. 515-8 4239" target="_blank" title="It opens in new window">CrossRef
20. Cooper, JC, Knutson, B (2008) Valence and salience contribute to nucleus accumbens activation. Neuroimage 39: pp. 538-47 CrossRef
21. Carter, RM, MacInnes, JJ, Huettel, SA, Adcock, RA (2009) Activation in the VTA and nucleus accumbens increases in anticipation of both gains and losses. Front Behav Neurol 3: pp. 21
22. Delgado, MR, Jou, RL, LeDoux, JE, Phelps, EA (2009) Avoiding negative outcomes: tracking the mechanisms of avoidance learning in humans during fear conditioning. Frontiers Behav Neurol 3: pp. 33
23. Jensen, J, McIntosh, AR, Crawley, AP, Mikulis, DJ, Remington, G, Kapur, S (2003) Direct activation of the ventral striatum in anticipation of aversive stimuli. Neuron 40: pp. 1251-7 4-4" target="_blank" title="It opens in new window">CrossRef
24. Seymour, B, Daw, N, Dayan, P, Singer, T, Dolan, R (2007) Differential encoding of losses and gains in the human striatum. J Neurosci 27: pp. 4826-31 400-07.2007" target="_blank" title="It opens in new window">CrossRef
25. Knutson, B, Adams, CM, Fong, GW, Hommer, D (2001) Anticipation of increasing monetary reward selectively recruits nucleus accumbens. J Neurosci 21: pp. 1-5
26. Elliott, R, Friston, KJ, Dolan, RJ (2000) Dissociable neural responses in human reward systems. J Neurosci 20: pp. 6159-65
27. Knutson, B, Westdorp, A, Kaiser, E, Hommer, D (2000) FMRI visualization of brain activity during a monetary incentive delay task. Neuroimage 12: pp. 20-7 CrossRef
28. Delgado, MR, Miller, MM, Inati, S, Phelps, EA (2005) An fMRI study of reward-related probability learning. Neuroimage 24: pp. 862-73 4.10.002" target="_blank" title="It opens in new window">CrossRef
29. O鈥橠oherty, J, Dayan, P, Schultz, J, Deichmann, R, Friston, K, Dolan, RJ (2004) Dissociable roles of ventral and dorsal striatum in instrumental conditioning. Science 304: pp. 452-4 4285" target="_blank" title="It opens in new window">CrossRef
30. O鈥橠oherty, J, Critchley, H, Deichmann, R, Dolan, RJ (2003) Dissociating valence of outcome from behavioral control in human orbital and ventral prefrontal cortices. J Neurosci 23: pp. 7931-9
31. Knutson, B, Greer, SM (2008) Anticipatory affect: neural correlates and consequences for choice. Philos Trans R Soc B Sci 363: pp. 3771-1 CrossRef
32. Simmons, A, Matthews, SC, Stein, MB, Paulus, MP (2004) Anticipation of emotionally aversive visual stimuli activates right insula. Neuroreport 15: pp. 2261-5 410050-00024" target="_blank" title="It opens in new window">CrossRef
33. Preuschoff, K, Quartz, SR, Bossaerts, P (2008) Human insula activation reflects risk prediction errors as well as risk. J Neurosci 28: pp. 2745-52 4286-07.2008" target="_blank" title="It opens in new window">CrossRef
34. Kim, H, Shimojo, S, O鈥橠oherty, JP (2006) Is avoiding an aversive outcome rewarding? Neural substrates of avoidance learning in the human brain. PLoS Biol 4: pp. e233 40233" target="_blank" title="It opens in new window">CrossRef
35. Schoenbaum, G, Chiba, AA, Gallagher, M (1998) Orbitofrontal cortex and basolateral amygdala encode expected outcomes during learning. Nat Neurosci 1: pp. 155-9 407" target="_blank" title="It opens in new window">CrossRef
36. Schoenbaum, G, Esber, GR (2010) How do you (estimate you will) like them apples? Integration as a defining trait of orbitofrontal function. Curr Opin Neurobiol 20: pp. 205-11 CrossRef
37. Tremblay, L, Schultz, W (2000) Modifications of reward expectation-related neuronal activity during learning in primate orbitofrontal cortex. J Neurophysiol 83: pp. 1877-85
38. Takahashi, YK, Roesch, MR, Wilson, RC, Toreson, K, O鈥橠onnell, P, Niv, Y (2011) Expectancy-related changes in firing of dopamine neurons depend on orbitofrontal cortex. Nat Neurosci 14: pp. 1590-7 CrossRef
39. Amiez, C, Joseph, JP, Procyk, E (2006) Reward encoding in the monkey anterior cingulate cortex. Cereb Cortex 16: pp. 1040-55 46" target="_blank" title="It opens in new window">CrossRef
40. Amiez, C, Joseph, JP, Procyk, E (2005) Anterior cingulate error鈥恟elated activity is modulated by predicted reward. Eur J Neurosci 21: pp. 3447-52 460-9568.2005.04170.x" target="_blank" title="It opens in new window">CrossRef
41. Yacubian, J, Gl盲scher, J, Schroeder, K, Sommer, T, Braus, DF, B眉chel, C (2006) Dissociable systems for gain-and loss-related value predictions and errors of prediction in the human brain. J Neurosci 26: pp. 9530-7 CrossRef
42. Hamann, SB, Ely, TD, Hoffman, JM, Kilts, CD (2002) Ecstasy and agony: activation of the human amygdala in positive and negative emotion. Psychol Sci 13: pp. 135-41 467-9280.00425" target="_blank" title="It opens in new window">CrossRef
43. Baxter, MG, Murray, EA (2002) The amygdala and reward. Nat Rev Neurosci 3: pp. 563-73 CrossRef
44. Balliet, D, Mulder, LB, Van Lange, PA (2011) Reward, punishment, and cooperation: a meta-analysis. Psychol Bull 137: pp. 594-615 489" target="_blank" title="It opens in new window">CrossRef
45. Kohls, G, Perino, MT, Taylor, JM, Madva, EN, Cayless, SJ, Troiani, V (2013) The nucleus accumbens is involved in both the pursuit of social reward and the avoidance of social punishment. Neuropsychologia 51: pp. 2062-9 CrossRef
46. Kaufman, AS, Kaufman, NL (1990) Kaufman brief intelligence test- second edition. American Guidance Service, Circle Pines, Minnesota
47. Lord, C, Risi, S, Lambrecht, L, Cook, EH, Leventhal, BL, DiLavore, PC (2000) The autism diagnostic observation schedule - generic: a standard measure of social and communication deficits associated with the spectrum of autism. J Autism Dev Disord 30: pp. 205-23 401947" target="_blank" title="It opens in new window">CrossRef
48. Gotham, K, Pickles, A, Lord, C (2009) Standardizing ADOS scores for a measure of severity in autism spectrum disorders. J Autism Dev Disord 39: pp. 693-705 4-3" target="_blank" title="It opens in new window">CrossRef
49. Hus, V, Lord, C (2014) The autism diagnostic observation schedule, module 4: revised algorithm and standardized severity scores. J Autism Dev Disord 44: pp. 1996-2012 4-2080-3" target="_blank" title="It opens in new window">CrossRef
50. Tottenham, N, Tanaka, JW, Leon, AC, McCarry, T, Nurse, M, Hare, TA (2009) The NimStim set of facial expressions: Judgments from untrained research participants. Psychiatry Res 168: pp. 242-9 CrossRef
51. Smith, SM (2002) Fast robust automated brain extraction. Hum Brain Mapp 17: pp. 143-55 CrossRef
52. Jenkinson, M, Bannister, P, Brady, M, Smith, SM (2002) Improved optimization for the robust and accurate linear registration and motion correction of brain images. Neuroimage 17: pp. 825-41 CrossRef
53. Smith, SM, Jenkinson, M, Woolrich, MW, Beckmann, CF, Behrens, TEJ, Johansen-Berg, H (2004) Advances in functional and structural MR image analysis and implementation as FSL. Neuroimage 23: pp. 208-19 4.07.051" target="_blank" title="It opens in new window">CrossRef
54. Jenkinson, M, Smith, SM (2001) A global optimisation method for robust affine registration of brain images. Med Image Anal 5: pp. 143-56 415(01)00036-6" target="_blank" title="It opens in new window">CrossRef
55. Wilke, M, Schmithorst, VJ, Holland, SK (2002) Assessment of spatial normalization of whole-brain magnetic resonance images in children. Hum Brain Mapp 17: pp. 48-60 CrossRef
56. Burgund, ED, Kang, HC, Kelly, JE, Buckner, RL, Snyder, AZ, Petersen, SE (2002) The feasibility of a common stereotactic space for children and adults in fMRI studies of development. Neuroimage 17: pp. 184-200 4" target="_blank" title="It opens in new window">CrossRef
57. Uddin, LQ, Davies, MS, Scott, AA, Zaidel, E, Bookheimer, SY, Iacoboni, M (2008) Neural basis of self and other representation in autism: an FMRI study of self-face recognition. PLoS One 3: pp. e3526 CrossRef
58. Bookheimer, SY, Wang, A, Scott, A, Sigman, M, Dapretto, M (2008) Frontal contributions to face processing differences in autism: evidence from fMRI of inverted face processing. J Int Neuropsychol Soc 14: pp. 922-32 40X" target="_blank" title="It opens in new window">CrossRef
59. Woolrich, MW, Ripley, BD, Brady, M, Smith, SM (2001) Temporal autocorrelation in univariate linear modeling of FMRI data. Neuroimage 14: pp. 1370-86 CrossRef
60. Beckmann, CF, Jenkinson, M, Smith, SM (2003) General multilevel linear modeling for group analysis in FMRI. Neuroimage 20: pp. 1052-63 435-X" target="_blank" title="It opens in new window">CrossRef
61. Constantino, JN, Gruber, CP (2002) The social responsiveness scale. Western Psychological Services, Los Angeles
62. White, SW, Koenig, K, Scahill, L (2010) Group social skills instruction for adolescents with high-functioning autism spectrum disorders. Focus Autism Dev Disabil 25: pp. 209-19 CrossRef
63. Scheeren, AM, Koot, HM, Begeer, S (2012) Social interaction style of children and adolescents with high-functioning autism spectrum disorder. J Autism Dev Disord 42: pp. 2046-55 451-x" target="_blank" title="It opens in new window">CrossRef
64. Benjamini, Y, Hochberg, Y (1995) Controlling the false discovery rate: a practical and powerful approach to multiple testing. J Royal Stat Soc Series B (Methodological) 57: pp. 289-300
65. Vul, E, Harris, C, Winkielman, P, Pashler, H (2009) Puzzlingly high correlations in fMRI studies of emotion, personality, and social cognition. Perspect Psychol Sci 4: pp. 274-90 45-6924.2009.01125.x" target="_blank" title="It opens in new window">CrossRef
66. McPartland, JC, Crowley, MJ, Perszyk, DR, Naples, AJ, Mukerji, CE, Wu, J (2011) Temporal dynamics reveal atypical brain response to social exclusion in autism. Dev Cogn Neurosci 1: pp. 271-9 CrossRef
67. Lin, A, Adolphs, R, Rangel, A (2012) Impaired learning of social compared to monetary rewards in autism. Front Neurosci 6: pp. 143 43" target="_blank" title="It opens in new window">CrossRef
68. Atallah, HE, Lopez-Paniagua, D, Rudy, JW, O鈥橰eilly, RC (2006) Separate neural substrates for skill learning and performance in the ventral and dorsal striatum. Nat Neurosci 10: pp. 126-31 CrossRef
69. W盲chter, T, Lungu, OV, Liu, T, Willingham, DT, Ashe, J (2009) Differential effect of reward and punishment on procedural learning. J Neurosci 29: pp. 436-43 4132-08.2009" target="_blank" title="It opens in new window">CrossRef
70. Graybiel, AM (2008) Habits, rituals, and the evaluative brain. Annu Rev Neurosci 31: pp. 359-87 46/annurev.neuro.29.051605.112851" target="_blank" title="It opens in new window">CrossRef
71. McClure, SM, Daw, ND, Read, MP (2003) A computational substrate for incentive salience. Trends Neurosci 26: pp. 423-8 CrossRef
72. Schultz, W, Dayan, P, Montague, PR (1997) A neural substrate of prediction and reward. Science 275: pp. 1593-9 CrossRef
73. Schultz, W, Dickinson, A (2000) Neuronal coding of prediction errors. Annu Rev Neurosci 23: pp. 473-500 46/annurev.neuro.23.1.473" target="_blank" title="It opens in new window">CrossRef
74. Seymour, B, O鈥橠oherty, JP, Dayan, P, Koltzenburg, M, Jones, AK, Dolan, RJ (2004) Temporal difference models describe higher-order learning in humans. Nature 429: pp. 664-7 CrossRef
75. Hikosaka, O, Nakamura, K, Nakahara, H (2006) Basal ganglia orient eyes to reward. J Neurophysiol 95: pp. 567-84 458.2005" target="_blank" title="It opens in new window">CrossRef
76. Schultz, W (1998) Predictive reward signal of dopamine neurons. J Neurophysiol 80: pp. 1-27
77. Belmonte, MK, Allen, G, Beckel-Mitchener, A, Boulanger, LM, Carper, RA, Webb, SJ (2004) Autism and abnormal development of brain connectivity. J Neurosci 24: pp. 9228-8 40-04.2004" target="_blank" title="It opens in new window">CrossRef
78. Di Martino, A, Kelly, C, Grzadzinski, R, Zuo, XN, Mennes, M, Mairena, MA (2010) Aberrant striatal functional connectivity in children with autism. Biol Psychiatry 69: pp. 847-56 CrossRef
79. Minshew, NJ, Goldstein, G (1998) Autism as a disorder of complex information processing. Ment Retard Dev Disabil Res Rev 4: pp. 129-36 4:2<129::AID-MRDD10>3.0.CO;2-X" target="_blank" title="It opens in new window">CrossRef
80. Williams, DL, Goldstein, G, Minshew, NJ (2006) Neuropsychologic functioning in children with autism: further evidence for disordered complex information-processing. Child Neuropsychol 12: pp. 279-98 40600681190" target="_blank" title="It opens in new window">CrossRef
81. Gastgeb, HZ, Rump, KM, Best, CA, Minshew, NJ, Strauss, MS (2009) Prototype formation in autism: can individuals with autism abstract facial prototypes?. Autism Res 2: pp. 279-84 CrossRef
82. Ropar, D, Peebles, D (2007) Sorting preference in children with autism: the dominance of concrete features. J Autism Dev Disord 37: pp. 270-80 CrossRef
83. Rogers, SJ (2000) Interventions that facilitate socialization in children with autism. J Autism Dev Disord 30: pp. 399-409 43321840" target="_blank" title="It opens in new window">CrossRef
84. McConnell, SR (2002) Interventions to facilitate social interaction for young children with autism: review of available research and recommendations for educational intervention and future research. J Autism Dev Disord 32: pp. 351-72 4" target="_blank" title="It opens in new window">CrossRef
85. Eshel, N, Nelson, EE, Blair, RJ, Pine, DS, Ernst, M (2007) Neural substrates of choice selection in adults and adolescents: development of the ventrolateral prefrontal and anterior cingulate cortices. Neuropsychologia 45: pp. 1270-9 4" target="_blank" title="It opens in new window">CrossRef
86. Galvan, A, Hare, TA, Parra, CE, Penn, J, Voss, H, Glover, G (2006) Earlier development of the accumbens relative to orbitofrontal cortex might underlie risk-taking behavior in adolescents. J Neurosci 26: pp. 6885-92 CrossRef - 刊物主题：Neurosciences; Neurobiology; Neuropsychology; Psychiatry; Human Genetics; Pediatrics;
- 出版者：BioMed Central
- ISSN：1866-1955
文摘
Background Previous research has found accumulating evidence for atypical reward processing in autism spectrum disorders (ASD), particularly in the context of social rewards. Yet, this line of research has focused largely on positive social reinforcement, while little is known about the processing of negative reinforcement in individuals with ASD. Methods The present study examined neural responses to social negative reinforcement (a face displaying negative affect) and non-social negative reinforcement (monetary loss) in children with ASD relative to typically developing children, using functional magnetic resonance imaging (fMRI). Results We found that children with ASD demonstrated hypoactivation of the right caudate nucleus while anticipating non-social negative reinforcement and hypoactivation of a network of frontostriatal regions (including the nucleus accumbens, caudate nucleus, and putamen) while anticipating social negative reinforcement. In addition, activation of the right caudate nucleus during non-social negative reinforcement was associated with individual differences in social motivation. Conclusions These results suggest that atypical responding to negative reinforcement in children with ASD may contribute to social motivational deficits in this population.