Retrospective analysis of treatment outcome of pediatric ependymomas in Korea: analysis of Korean multi-institutional data

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• 作者：Yeon-Joo Kim (1)
  Joo-Young Kim (1) (6)
  Do Hoon Lim (2)
  Hyeon Jin Park (1)
  Jungnam Joo (1)
  Ki Woong Sung (2)
  Hyung Jin Shin (2)
  Seung-Ki Kim (3)
  Ji Hoon Phi (3)
  Il Han Kim (3)
  Kyung Duk Park (3)
  Seung-do Ahn (4)
  Jinhong Jung (4)
  Young Sin Rha (4)
  Dong-Seok Kim (5)
  Chang-Ok Suh (5)
  
• 关键词：Pediatric ependymomas ; Radiotherapy ; Age ; Local control ; Overall survival
• 刊名：Journal of Neuro-Oncology
• 出版年：2013
• 出版时间：May 2013
• 年：2013
• 卷：113
• 期：1
• 页码：39-48
• 全文大小：453KB
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  2. Timmermann B, Kortmann RD, Kuhl J, Rutkowski S, Dieckmann K, Meisner C, Bamberg M (2005) Role of radiotherapy in anaplastic ependymoma in children under age of 3?years: results of the prospective German brain tumor trials HIT-SKK 87 and 92. Radiother Oncol 77:278-85. doi:10.1016/j.radonc.2005.10.016 CrossRef
  3. McGuire CS, Sainani KL, Fisher PG (2009) Both location and age predict survival in ependymoma: a SEER study. Pediatr Blood Cancer 52:65-9. doi:10.1002/pbc.21806 CrossRef
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  7. Timmermann B, Kortmann RD, Kuhl J, Meisner C, Slavc I, Pietsch T, Bamberg M (2000) Combined postoperative irradiation and chemotherapy for anaplastic ependymomas in childhood: results of the German prospective trials HIT 88/89 and HIT 91. Int J Radiat Oncol Biol Phys 46:287-95 CrossRef
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  10. Grundy RG, Wilne SA, Weston CL, Robinson K, Lashford LS, Ironside J, Cox T, Chong WK, Campbell RH, Bailey CC, Gattamaneni R, Picton S, Thorpe N, Mallucci C, English MW, Punt JA, Walker DA, Ellison DW, Machin D (2007) Primary postoperative chemotherapy without radiotherapy for intracranial ependymoma in children: the UKCCSG/SIOP prospective study. Lancet Oncol 8:696-05. doi:10.1016/S1470-2045(07)70208-5 CrossRef
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• 作者单位：Yeon-Joo Kim (1)
  Joo-Young Kim (1) (6)
  Do Hoon Lim (2)
  Hyeon Jin Park (1)
  Jungnam Joo (1)
  Ki Woong Sung (2)
  Hyung Jin Shin (2)
  Seung-Ki Kim (3)
  Ji Hoon Phi (3)
  Il Han Kim (3)
  Kyung Duk Park (3)
  Seung-do Ahn (4)
  Jinhong Jung (4)
  Young Sin Rha (4)
  Dong-Seok Kim (5)
  Chang-Ok Suh (5)
  
  1. Research Institute and Hospital, National Cancer Center, Goyang, South Korea
  6. Center for Proton Therapy, National Cancer Center, 809 Madu 1-dong, Goyang-si, Gyeonggi-do, 411-769, South Korea
  2. Samsung Medical Center, Seoul, South Korea
  3. Seoul National University Children’s Hospital, Seoul, South Korea
  4. Asan Medical Center, Seoul, South Korea
  5. Yonsei University Severance Hospital, Seoul, South Korea
  
• ISSN：1573-7373

文摘

We analyzed the treatment outcomes of intracranial ependymomas in Korean children aged <18?years. Data for 96 patients were collected from five hospitals. Survival rates were calculated using the Kaplan–Meier method. Log-rank tests for univariate analyses and Cox regression model for multivariate analysis were conducted to identify prognostic factors for survival. The median age of the patients was 4?years (range, 0.3-7.9?years). The median follow-up was 55?months (range, 2-43?months). Age <3?years was an important factor for selecting adjuvant therapy after surgery. Among children aged <3 and ??years, adjuvant radiotherapy (RT) was applied to 55 and 84?%, respectively, and adjuvant chemotherapy to 52 and 10?%, respectively. The 5?year local progression-free survival (LPFS), disease-free survival (DFS), and overall survival (OS) rates were 54, 52, and 79?%, respectively. Gross total resection was the most significant prognostic factor for all survival endpoints. Age ??years and RT were significant prognostic factors for superior LPFS and DFS. However, the significance of age was lost in multivariate analysis?for DFS. LPFS, DFS, and OS were superior in patients who started RT within 44?days after surgery (the median time) than in patients who started RT later?in the patients aged ? years. Postoperative RT was a strong prognostic factor for intracranial ependymomas. Our results suggest that early use of RT is an essential component of treatment, and should be considered in young children.