Regression of an enchondroma: a case report and proposed etiology

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• 作者：Anirban Sensarma (1)
  John E. Madewell (1)
  Jeanne M. Meis (2)
  Rajendra Kumar (1)
  Patrick P. Lin (3)
  Behrang Amini (1)
  
  1. Department of Diagnostic Radiology ; The University of Texas MD Anderson Cancer Center ; 1400 Pressler Street ; Unit 1475 ; Houston ; TX ; 77030 ; USA
  2. Department of Pathology ; The University of Texas MD Anderson Cancer Center ; Houston ; TX ; USA
  3. Department of Orthopedic Oncology ; The University of Texas MD Anderson Cancer Center ; Houston ; TX ; USA
  
• 关键词：Enchondroma ; Regression ; Radiography ; MRI
• 刊名：Skeletal Radiology
• 出版年：2015
• 出版时间：May 2015
• 年：2015
• 卷：44
• 期：5
• 页码：739-742
• 全文大小：2,011 KB
• 参考文献：1. Lucas, DR, Bridge, JA Chondromas: enchondroma, periosteal chondroma, and enchondromatosis. In: Fletcher, CDM, Unni, KK, Mertens, F eds. (2002) Pathology and genetics of tumours of soft tissue and bone. IARC Press, Lyon, pp. 237-240
  2. Brien, EW, Mirra, JM, Kerr, R (1997) Benign and malignant cartilage tumors of bone and joint: their anatomic and theoretical basis with an emphasis on radiology, pathology and clinical biology. I. The intramedullary cartilage tumors. Skelet Radiol 26: pp. 325-353 CrossRef
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  11. Dirckx, N, Hul, M, Maes, C (2013) Osteoblast recruitment to sites of bone formation in skeletal development, homeostasis, and regeneration. Birth Defects Res Part C Embryo Today: Reviews 99: pp. 170-191
  
• 刊物类别：Medicine
• 刊物主题：Medicine & Public Health
  Imaging and Radiology
  Orthopedics
  Pathology
  Nuclear Medicine
  
• 出版者：Springer Berlin / Heidelberg
• ISSN：1432-2161

文摘

Enchondromas are common benign bone lesions that are found in the medullary cavity of tubular bones, usually at the metaphysis. Regression is highly unusual, and loss of matrix mineralization in an existing enchondroma should prompt investigation for malignant transformation. We present the case of a 50-year-old woman with an enchondroma of the proximal humeral metadiaphysis, which underwent loss of matrix mineralization that corresponded to replacement with marrow fat on MRI. This transformation of the cartilage tumor matrix into normal bone marrow may occur in a process similar to that seen with endochondral ossification.