Ambulatory sentinel lymph node biopsy preceding neoadjuvant therapy in patients with operable breast cancer: a preliminary study

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• 作者：Shinichiro Kashiwagi (1)
  Naoyoshi Onoda (1)
  Yuka Asano (1)
  Kento Kurata (1)
  Satoru Noda (1)
  Hidemi Kawajiri (1)
  Tsutomu Takashima (1)
  Masahiko Ohsawa (2)
  Seiichi Kitagawa (3)
  Kosei Hirakawa (1)
  
  1. Department of Surgical Oncology ; Osaka City University Graduate School of Medicine ; 1-4-3 Asahi-machi ; Abeno-ku ; Osaka ; 545-8585 ; Japan
  2. Department of Diagnostic Pathology ; Osaka City University Graduate School of Medicine ; 1-4-3 Asahi-machi ; Abeno-ku ; Osaka ; 545-8585 ; Japan
  3. Department of Physiology ; Osaka City University Graduate School of Medicine ; 1-4-3 Asahi-machi ; Abeno-ku ; Osaka ; 545-8585 ; Japan
  
• 关键词：Breast cancer ; Operation ; Ambulatory surgical procedure ; Sentinel lymph node biopsy ; False negative
• 刊名：World Journal of Surgical Oncology
• 出版年：2015
• 出版时间：December 2015
• 年：2015
• 卷：13
• 期：1
• 全文大小：511 KB
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• 刊物主题：Surgical Oncology;
• 出版者：BioMed Central
• ISSN：1477-7819

文摘

Background Sentinel lymph node biopsy (SNB)-oriented stepwise treatment under local anesthesia has been performed in the outpatient-ambulatory setting in patients receiving neoadjuvant therapy (NAT). We retrospectively reviewed our preliminary experience of ambulatory SNB in breast cancer patients scheduled to undergo NAT to evaluate the usefulness and feasibility of this method as a minimally invasive, stepwise treatment protocol. Methods We retrospectively identified 56 patients with breast cancer without obvious nodal involvement who were scheduled to receive NAT before breast surgery. SNB was performed under local anesthesia in an ambulatory outpatient setting before the initiation of NAT. Results The average number of removed sentinel lymph nodes was 1.9. Identification of the sentinel node was possible in all cases, and macrometastasis was observed in six cases (10.7%). Micrometastasis was observed in five cases, while isolated tumor cells were noted in six cases. There were no delays in the initiation of NAT as a result of complications of SNB. Conclusions This pilot study demonstrated the safety and feasibility of ambulatory SNB prior to NAT. Further studies are warranted to assess the strict indications, patient satisfaction, and medical economics of this procedure.