Surgery for hypertrophic cardiomyopathy
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  • 作者:James J. Wu (1) (2) (3)
    Michael Seco (1) (2) (3)
    Caroline Medi (4) (5)
    Chris Semsarian (1) (4) (5)
    David R. Richmond (5)
    Joseph A. Dearani (6)
    Hartzell V. Schaff (6)
    Michael J. Byrom (2) (3)
    Paul G. Bannon (1) (2) (3)

    1. Sydney Medical School
    ; The University of Sydney ; Sydney ; Australia
    2. The Baird Institute of Applied Heart & Lung Surgical Research
    ; Sydney ; Australia
    3. Cardiothoracic Surgery Unit
    ; Royal Prince Alfred Hospital ; Sydney ; Australia
    4. Molecular Cardiology Group
    ; Centenary Institute ; Sydney ; NSW ; Australia
    5. Department of Cardiology
    ; Royal Prince Alfred Hospital ; Sydney ; NSW ; Australia
    6. Cardiac Surgery Unit
    ; Mayo Clinic ; Rochester ; MN ; USA
  • 关键词:Hypertrophic cardiomyopathy ; Septal myectomy ; Alcohol septal ablation ; Left ventricular outflow tract obstruction
  • 刊名:Biophysical Reviews
  • 出版年:2015
  • 出版时间:March 2015
  • 年:2015
  • 卷:7
  • 期:1
  • 页码:117-125
  • 全文大小:756 KB
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  • 刊物类别:Physics and Astronomy
  • 刊物主题:Physics
    Biophysics and Biomedical Physics
    Cell Biology
    Biochemistry
    Biological Techniques
    Biomedicine
    Nanotechnology
  • 出版者:Springer Berlin / Heidelberg
  • ISSN:1867-2469
文摘
Hypertrophic cardiomyopathy (HCM) is a genetically determined cardiac disease characterised by otherwise unexplained myocardial hypertrophy of the left ventricle, and may result in left ventricular outflow tract obstruction. It is the most common cause of sudden cardiac death in young adults due to arrhythmias. Septal myectomy is a surgical treatment for HCM with moderate to severe outflow tract obstruction, and is indicated for patients with severe symptoms refractory to medical therapy. The surgical approach involves obtaining access to the interventricular septum via transaortic, transapical or transmitral approaches, and excising a portion of the hypertrophied myocardium to relieve the outflow tract obstruction. Large, contemporary series from centres experienced in septal myectomy patients have demonstrated a low early mortality of

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