Engrailed homeoproteins in visual system development

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• 作者：Andrea Wizenmann (1)
  Olivier Stettler (2)
  Kenneth L. Moya (3) (4)
  
  1. Department of Anatomy ; Institute of Clinical Anatomy and Cell Analysis ; University of T眉bingen ; 脰sterbergstrasse 3 ; 72074 ; T眉bingen ; Germany
  2. Laboratoire CRRET EAC 7149 ; Universit茅 Paris-Est Cr茅teil ; 61 ; Av. du G茅n茅ral de Gaulle ; 94010 ; Cr茅teil Cedex ; France
  3. Coll猫ge de France ; Center for Interdisciplinary Research in Biology ; UMR CNRS 7241/INSERM U1050 ; 11 place Marcelin Berthelot ; 75005 ; Paris ; France
  4. Labex Memolife ; PSL Research University ; Paris ; France
  
• 关键词：Visual system ; Retina ; Tectum ; Sensory map ; Homeoprotein ; Engrailed
• 刊名：Cellular and Molecular Life Sciences (CMLS)
• 出版年：2015
• 出版时间：April 2015
• 年：2015
• 卷：72
• 期：8
• 页码：1433-1445
• 全文大小：2,734 KB
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• 刊物类别：Biomedical and Life Sciences
• 刊物主题：Life Sciences
  Cell Biology
  Biomedicine
  Life Sciences
  Biochemistry
  
• 出版者：Birkh盲user Basel
• ISSN：1420-9071

文摘

Engrailed is a homeoprotein transcription factor. This family of transcription factors is characterized by their DNA-binding homeodomain and some members, including Engrailed, can transfer between cells and regulate protein translation in addition to gene transcription. Engrailed is intimately involved in the development of the vertebrate visual system. Early expression of Engrailed in dorsal mesencephalon contributes to the development and organization of a visual structure, the optic tectum/superior colliculus. This structure is an important target for retinal ganglion cell axons that carry visual information from the retina. Engrailed regulates the expression of Ephrin axon guidance cues in the tectum/superior colliculus. More recently it has been reported that Engrailed itself acts as an axon guidance cue in synergy with the Ephrin system and is proposed to enhance retinal topographic precision.