Factors associated with one year retention to methadone maintenance treatment program among patients with heroin dependence in China

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• 作者：Haifeng Jiang (1)
  Yun Han (2)
  Jiang Du (1)
  Fei Wu (3)
  Ruimin Zhang (4)
  Huaihui Zhang (5)
  Jun Wang (5)
  Zhirong Zhou (6)
  Yih-Ing Hser (3) (7)
  Min Zhao (1)
  
• 关键词：Heroin dependence ; Methadone maintenance treatment ; Survival analysis
• 刊名：Substance Abuse Treatment, Prevention, and Policy
• 出版年：2014
• 出版时间：December 2014
• 年：2014
• 卷：9
• 期：1
• 全文大小：180 KB
• 参考文献：1. Chinese Ministry of Public Security: / 2012 Annual Report on Drug Control in China. Beijing; 2012. (in Chinese) Available at: http://www.zjjd.org/hot/2012-1/12/content_9989.html
  2. National Working Group on Community–based Methadone Maintenance Treatment for Opium Dependents. Scaling-up methadone maintenance treatment program in China. Talk presented at UNETG meeting on 25 February 2009in Chinese) Available at: http://www.unaids.org.cn/download/UNETG-090225-NCAIDS.ppt (accessed 11 February 2012 in Chinese) Available at: (accessed 11 February 2012
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• 作者单位：Haifeng Jiang (1)
  Yun Han (2)
  Jiang Du (1)
  Fei Wu (3)
  Ruimin Zhang (4)
  Huaihui Zhang (5)
  Jun Wang (5)
  Zhirong Zhou (6)
  Yih-Ing Hser (3) (7)
  Min Zhao (1)
  
  1. Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, 200030, China
  2. University of Michigan, Ann Arbor, MI, USA
  3. University of California, Los Angeles, CA, USA
  4. Yunnan Institute on Drug Abuse, Kunming, Yunnan, China
  5. Shanghai Yangpu District Mental Health Center, Shanghai, China
  6. Shanghai Xuhui District Mental Health Center, Shanghai, China
  7. UCLA Integrated Substance Abuse Programs, 1640 Sepulveda Blvd., Los Angeles, CA, 90025, USA
  
• ISSN：1747-597X

文摘

Objective The aim of this study was to evaluate the risk factors associated with dropout from Methadone Maintenance Treatment (MMT) clinics within a 1?year follow-up cohort study in China. Methods A data analysis is to explore the adherence of MMT during one year from three hundred and twenty patients with heroin dependence at five clinics (3 in Shanghai, 2 in Kunming) in China. All participants were from the part of China-United States cooperation project entitled “Research about improving the compliance and efficacy of methadone maintenance treatment in China- Our data analysis includes the patients-attendance in the 6?months clinical study and the data in another 6?months afterward. The data of patients at baseline were collected with the Addiction Severity Index (ASI) which is a semi-structured questionnaire covering socio-demographic characteristics and drug use history. The one year attendance after recruitment at the clinics and daily dose were abstracted from the MMT clinic register system. The Cox proportional hazards model were used to explore the risk factor of dropout, defined as seven consecutive days without methadone. Results By the end of 1?year of treatment 86 patients still remained in MMT without dropout (87% in Shanghai and 13% patients in Kunming). Over the entire 1-year period the median days of remaining in the program were 84?days (in Shanghai and Kunming were 317?days and 22?days).The factors associated with retention included age (HR--.98, 95%C.I.:0.96-0.99, P--.0062) and ASI alcohol scores (HR--.72, 95%C.I.:1.49-21.92, P--.0109) at baseline. Conclusion One year retention of newly recruited patients with heroin dependence was related to age and ASI alcohol scores at baseline. The adherence is poorer for the patients who are young and having more serious alcohol problems.