A mass-spectrometric study of the aqueous solutions of opiates with their ionization in a collison nebulizer

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• 作者：V. V. Pervukhin ; D. G. Sheven’
• 刊名：Journal of Analytical Chemistry
• 出版年：2016
• 出版时间：September 2016
• 年：2016
• 卷：71
• 期：9
• 页码：878-887
• 全文大小：689 KB
• 刊物类别：Chemistry and Materials Science
• 刊物主题：Chemistry
  Analytical Chemistry
  Russian Library of Science
  
• 出版者：MAIK Nauka/Interperiodica distributed exclusively by Springer Science+Business Media LLC.
• ISSN：1608-3199
• 卷排序：71

文摘

It was found that the use of a Collison nebulizer as an ionization source for the mass-spectrometric analysis of the aqueous solutions of opium alkaloids makes it possible to determine opiates with the limits of detection of 8.8 × 10–9, 8.83 × 10–8, 1.6 × 10–7, and 3.5 × 10–8 M for papaverine, codeine, heroin, and morphine, respectively. The dependence of mass-spectrometric responses [(M + H)+ ions] on the concentrations of these compounds in water in a range from 10–8 to 10–3 M appears as a curve with a maximum; this is explained by the consideration of the most probable mechanisms of the ionization of drops on liquid spraying in a Collison nebulizer (a model of the destruction of a double electrical layer and a model of statistical fluctuations, which is also known as a model of symmetrical charging). The transformation of the mass spectrum of a mixture (1: 1: 1: 1) of morphine, codeine, papaverine, and heroin was studied on varying the concentration of this mixture in aqueous solution. Two samples of opium of Central-Asian origin were analyzed to test the applicability of ionization in a Collison nebulizer to the analysis of real test materials.Keywordsmass spectrometryCollison nebulizeropiates