Sessile serrated adenoma/polyps with a depressed surface: a rare form of sessile serrated adenoma/polyp

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• 作者：Eun-Jung Lee ; Mi-Jung Kim ; Sung-Min Chun ; Se-Jin Jang ; Do Sun Kim…
• 关键词：Sessile serrated adenoma ; Colon ; Endoscopy ; Serrated polyp
• 刊名：Diagnostic Pathology
• 出版年：2015
• 出版时间：December 2015
• 年：2015
• 卷：10
• 期：1
• 全文大小：3,242 KB
• 刊物主题：Pathology;
• 出版者：BioMed Central
• ISSN：1746-1596

文摘

Sessile serrated adenoma/polyps (SSA/Ps) usually appear flat to sessile with a smooth-appearing surface. However, macroscopic appearances of SSA/P can vary from flat-elevated to nodular and can even show a pedunculated configuration as we previously reported. The aim of the current study was to evaluate the clinicopathologic features of another under-recognized form of SSA/P which shows a depressed surface. Among 634 cases of sessile serrated adenoma/polyp, a total of seven sessile serrated adenoma/polyps showing a depressed surface were identified in 6 patients during the review of endoscopic images between January 2013 and November 2013. One of these was found during the review of previous endoscopic images of the same patient. Patients were more often middle-aged to elderly men (83.3 %) and had synchronous conventional adenomas and/or SSA/Ps except for one man. The polyps usually occurred in the proximal colon (71.4 %) and the mean size of polyps was 9.3 mm (range; 6-13 mm). Most cases (71.4 %) were of a flat-elevated type, and the remaining polyps (28.6 %) were sessile. The majority of polyps (85.7 %) showed a mucus cap. All but one of the cases (85.7 %) showed BRAF-V600E mutations. Our findings are that SSA/Ps can show a central depression although such cases are rare. The endoscopic and clinicopathologic features of SSA/Ps showing a depressed surface appear to be similar to usual SSA/Ps except for the presence of a depressed surface and marked male preponderance.